Chapter 30. Brain Metastases

  1. Nils Erik Gilhus MD, PhD Professor15,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director16 and
  3. Michael Brainin MD Professor17
  1. R. Soffietti1,
  2. P. Cornu2,
  3. J. Y. Delattre3,
  4. R. Grant4,
  5. F. Graus5,
  6. W. Grisold6,
  7. J. Heimans7,
  8. J. Hildebrand8,
  9. P. Hoskin9,
  10. M. Kalljo10,
  11. P. Krauseneck11,
  12. C. Marosi12,
  13. T. Siegal13 and
  14. C. Vecht14

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch30

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Brain Metastases, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch30

Author Information

  1. 15

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 16

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 17

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    San Giovanni Battista Hospital and University, Torino, Italy

  2. 2

    Pitié-Salpétrière and University, Paris, France

  3. 3

    Pitié-Salpétrière, Paris, France

  4. 4

    Western General Hospital and University, Edinburgh, UK

  5. 5

    Hospital Clinic, Villaroel, Barcelona Spain

  6. 6

    Kaiser-Franz-Josef Spital, Vienna Austria

  7. 7

    Academisch Ziekenhuis V.U., Amsterdam, The Netherlands

  8. 8

    Brussels, Belgium

  9. 9

    Mount Vernon Hospital and University, Northwood, Middlesex, UK

  10. 10

    University Hospital, Helsinki, Finland

  11. 11

    Neurologische Clinic, Bamberg, Germany

  12. 12

    Vienna General Hospital and University, Vienna, Austria

  13. 13

    Hadassah Hebrew University, Jerusalem, Israel

  14. 14

    Med Center Haaglanden, The Hague, The Netherlands

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • brain metastases;
  • primary objective, evidence-based guidelines - management of patients with brain metastases;
  • headache, focal neurological deficits and seizures - most common presenting symptoms;
  • dexamethasone, used to control cerebral oedema;
  • treatment of single brain metastasis;
  • stereotactic radiosurgery (SRS) - permitting delivery of single high dose of radiation;
  • anticoagulant therapy, standard treatment for acute venous thromboembolism (VTE) - in cancer patients;
  • whole-brain radiotherapy alone;
  • treatment of multiple brain metastases;
  • molecularly targeted therapies - investigated in recent years, in patients with brain metastases


This chapter contains sections titled:

  • Objectives

  • Background

  • Search strategy

  • Method for reaching consensus

  • Review of the evidence

  • References