Chapter 31. Paraneoplastic Neurological Syndromes

  1. Nils Erik Gilhus MD, PhD Professor10,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director11 and
  3. Michael Brainin MD Professor12
  1. C. A. Vedeler1,
  2. J. C. Antoine2,
  3. B. Giometto3,
  4. F. Graus4,
  5. W. Grisold5,
  6. J. Honnorat6,
  7. P. A. E. Sillevis Smitt7,
  8. J. J. G. M. Verschuuren8 and
  9. R. Voltz9

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch31

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Paraneoplastic Neurological Syndromes, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch31

Author Information

  1. 10

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 11

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 12

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Haukeland University Hospital and University of Bergen, Norway

  2. 2

    Hopital Bellevue, Saint Etienne, France

  3. 3

    University of Padua, Italy

  4. 4

    Institut d'Investigacio Biomedica August Pi I Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Spain

  5. 5

    Kaiser Franz Josef hospital and Ludwig Boltzmann Institute for Neurooncology, Vienna, Austria

  6. 6

    Hospital Neurologique, Lyon, France

  7. 7

    Erasmus University Medical Center, Rotterdam, The Netherlands

  8. 8

    Leiden University Medical Center, The Netherlands

  9. 9

    University of Cologne, Germany

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394

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Keywords:

  • paraneoplastic neurological syndromes;
  • paraneoplastic neurological syndromes (PNS) - defined as neurological syndromes of unknown;
  • European Federation of Neurological Societies (EFNS) task force - part of PNS Euronetwork, outlining guidelines for management of classical PNS;
  • paraneoplastic limbic encephalitis (PLE) - characterized by acute, or subacute onset of symptoms;
  • three types of antibodies against different surface neuronal receptors - identified in patients with PLE;
  • subacute sensory neuronopathy (SSN) - regarded as a classical PNS;
  • paraneoplastic cerebellar degeneration (PCD) - characterized by subacute development of severe pancerebellar dysfunction;
  • paraneoplastic opsoclonus, myoclonus - Opsoclonus meaning involuntary eye movements in any direction;
  • Lambert-Eaton myasthenic syndrome;
  • paraneoplastic peripheral nerve hyperexcitability syndromes

Summary

This chapter contains sections titled:

  • Background

  • Methods

  • Paraneoplastic limbic encephalitis

  • Subacute sensory neuronopathy

  • Paraneoplastic opsoclonus-myoclonus

  • Paraneoplastic cerebellar degeneration

  • Lambert-Eaton myasthenic syndrome

  • Paraneoplastic peripheral nerve hyperexcitability syndromes

  • Acknowledgements

  • References