Chapter 33. Orthostatic Hypotension

  1. Nils Erik Gilhus MD, PhD Professor6,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director7 and
  3. Michael Brainin MD Professor8
  1. H. Lahrmann1,
  2. P. Cortelli2,
  3. M. Hilz3,
  4. C. J. Mathias4,
  5. W. Struhal5 and
  6. M. Tassinari2

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch33

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Orthostatic Hypotension, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch33

Author Information

  1. 6

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 7

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 8

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Kaiser Franz Josef Hospital and L. Boltzmann Institute for Neurooncology, Vienna, Austria

  2. 2

    University of Bologna, Italy

  3. 3

    University Erlangen - Nuremberg, Erlangen, Germany, and New York University, School of Medicine, NY, USA

  4. 4

    Imperial College London at St Mary's Hospital, and National Hospital for Neurology and Neurosurgery, Queen Square, and Institute of Neurology, University College London, UK

  5. 5

    General Hospital (AKH), Linz, Austria

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • orthostatic hypotension;
  • orthostatic (postural) hypotension (OH), frequent cause of syncope - contributing to morbidity, disability and even death;
  • orthostatic hypotension, an under-diagnosed disorder;
  • electronic search strategies - using databases, as Cochrane library, MEDLINE, Pub Med;
  • supine hypertension, being a problem - from medication or as part of the disease;
  • patients, advised to move to head-up position slowly - sitting on the edge of the bed for some minutes after recumbence;
  • elastic stockings and abdominal compression bands - reducing venous pooling, effective;
  • Midodrine, a prodrug with - active metabolite, desglymidodrine;
  • Dihydroxyphenylserine (DOPS), a prodrug converted by dopadecarboxylase - to noradrenaline;
  • Octreotide Thesomatostatin analogue - inhibiting release of gastrointestinal peptides, having vasodilatatory properties


This chapter contains sections titled:

  • Background

  • Objectives

  • Methods

  • Diagnostic strategies

  • Management

  • Summary

  • Need of update

  • References