36. Neurological Problems in Liver Transplantation

  1. Nils Erik Gilhus MD, PhD Professor6,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director7 and
  3. Michael Brainin MD Professor8
  1. M. Guarino1,
  2. J. Benito-León2,
  3. E. Schmutzhard3,
  4. K. Weissenborn4,
  5. J. Decruyenaere5 and
  6. A. Stracciari1

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch36

European Handbook of Neurological Management, Second Edition

European Handbook of Neurological Management, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Neurological Problems in Liver Transplantation, in European Handbook of Neurological Management, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch36

Author Information

  1. 6

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 7

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 8

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    S. Orsola-Malpighi University Hospital, Bologna, Italy

  2. 2

    University Hospital 12 de Octubre, Madrid, Spain and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

  3. 3

    Ghent University Hospital, Belgium

  4. 4

    Innsbruck Medical University, Austria

  5. 5

    Hannover Medical School, Germany

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • neurological problems in liver transplantation;
  • neurological problems, in patients - after orthotopic liver transplantation (LT);
  • Task Force, European Federation of Neurological Societies (EFNS) - devising guidelines to prevent and manage neurological problems in LT;
  • immunosuppression neurotoxicity;
  • neurotoxicity, occurring early after surgery - not always related to high drug plasma levels;
  • minor side effects, transient and self-limiting - headache, tremor, paraesthesiae, and insomnia managed with symptomatic conventional treatment (Class IV);
  • central pontine myelinolysis (CPM);
  • neuromuscular disorders - presenting with focal or generalized weakness;
  • CNS infections in LT recipients - favoured by immunosuppression;
  • treatment, based on guidelines - for immunocompromised patients and LT centres' experience


This chapter contains sections titled:

  • Introduction

  • Search strategy

  • Grading of recommendations

  • Results

  • References