Chapter 38. Management of Narcolepsy in Adults

  1. Nils Erik Gilhus MD, PhD Professor7,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director8 and
  3. Michael Brainin MD Professor9
  1. M. Billiard1,
  2. Y. Dauvilliers2,
  3. L. Dolenc-Grošelj3,
  4. G.J. Lammers4,
  5. G. Mayer5 and
  6. K. Sonka6

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch38

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Management of Narcolepsy in Adults, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch38

Author Information

  1. 7

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 8

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 9

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    University of Montpellier, France

  2. 2

    Gui de Chauliac Hospital, Montpellier, France

  3. 3

    University Medical Center, Ljubljana, Slovenia

  4. 4

    Leiden University Medical Center, The Netherlands

  5. 5

    Department of Neurology, Schwalmstadt-Treysa, Germany

  6. 6

    Charles University, Prague, Czech Republic

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • sleep disorders - management of narcolepsy in adults;
  • treatments used for narcolepsy, either pharmacological or behavioural, being diverse;
  • multiple sleep latency test (MSLT) - an objective test of sleepiness based on 20-min polygraphic recording sessions;
  • narcolepsy, a disabling syndrome - first described by Westphal and Gelineau;
  • diagnosis of narcolepsy with cataplexy - confirmed by nocturnal polysomnography followed by MSLT;
  • several databases used, the Cochrane Library, MEDLINE, EMBASE, and clinical trials;
  • excessive daytime sleepiness and irresistible episodes of sleep;
  • sodium oxybate, approved for treatment of narcolepsy - with cataplexy in adults by EMEA;
  • Maintenance of Wakefulness Test (MWT) - significant decrease in likelihood of falling asleep measured by Epworth Sleepiness Scale (ESS);
  • current treatments for human narcolepsy - symptomatically based


This chapter contains sections titled:

  • Introduction

  • Methods and search strategy

  • Methods for reaching consensus

  • Results

  • References