Chapter 6. Use of Antibody Testing in Nervous System Disorders

  1. Nils Erik Gilhus MD, PhD Professor7,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director8 and
  3. Michael Brainin MD Professor9
  1. H. J. Willison1,
  2. N. E. Gilhus2,
  3. F. Graus3,
  4. B. C. Jacobs4,
  5. R. Liblau5,
  6. C. Vedeler2 and
  7. A. Vincent6

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch6

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Use of Antibody Testing in Nervous System Disorders, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch6

Author Information

  1. 7

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 8

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 9

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK

  2. 2

    Haukeland University Hospital and University of Bergen, Bergen, Norway

  3. 3

    Hospital Clinic de Barcelona, Spain

  4. 4

    Erasmus MC, Rotterdam, The Netherlands

  5. 5

    Hopital de la Salpetriere, Paris, France

  6. 6

    Institute of Molecular Medicine, John Raddiffe Hospital, Oxford, UK

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • use of antibody testing in nervous system disorders;
  • anti-neuronal antibodies, associated with paraneoplastic syndromes, anti-Hu anti-Yo, and anti-Ri;
  • antigens tested - and their associated diseases;
  • EFNS Scientific Panel on Neuroimmunology, anti-nerve antibody task force - for conducting reviews;
  • antibodies to glutamic acid decarboxylase (GAD) - in autoimmune stiff person syndrome;
  • antibody assays to voltage-gated calcium channels (VGCC) and potassium channels (VGKC) – rarely conducted;
  • questions on quality assurance - centres reporting in-house quality assurance;
  • co-operative inter-laboratory studies - conducted through distribution of coded positive and negative samples to participating laboratories


This chapter contains sections titled:

  • Objective

  • Background

  • Methods

  • Results

  • Discussion and Good Practice Points

  • References