Chapter 8. Assessment of Neuropathic Pain

  1. Nils Erik Gilhus MD, PhD Professor11,
  2. Michael P. Barnes MD, FRCP Professor of Neurological Rehabilitation Medical Director12 and
  3. Michael Brainin MD Professor13
  1. G. Cruccu1,
  2. C. Sommer2,
  3. P. Anand3,
  4. N. Attal4,
  5. R. Baron5,
  6. L. Garcia-Larrea6,
  7. M. Haanpää7,
  8. T. S. Jensen8,
  9. J. Serra9 and
  10. R.-D. Treede10

Published Online: 6 SEP 2010

DOI: 10.1002/9781444328394.ch8

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition

How to Cite

Gilhus, N. E., Barnes, M. P. and Brainin, M. (2010) Assessment of Neuropathic Pain, in European Handbook of Neurological Management, Second Edition, Volume 1, Second Edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444328394.ch8

Author Information

  1. 11

    Department of Clinical Medicine, University of Bergen and Department of Neurology, Haukeland University Hospital, Bergen, Norway

  2. 12

    University of Newcastle, Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  3. 13

    Department of Clinical Medicine and Prevention, and Center for Clinical Neurosciences, Donau-Universität Krems, Department of Neurology, Landesklinikum Donauregion Tulln Tulln, Austria

Author Information

  1. 1

    La Sapienza University, Rome, Italy

  2. 2

    University of Würzburg, Germany

  3. 3

    Imperial College London, UK

  4. 4

    Hôpital Ambroise Paré, APHP, Boulogne - Billancourt, France

  5. 5

    Universitatsklinikum Schleswig-Holstein, Kiel, Germany

  6. 6

    Hôpital Neurologique, Lyon, France

  7. 7

    Helsinki University Hospital, Finland

  8. 8

    Aarhus University Hospital, Denmark

  9. 9

    MC Mutual, Barcelona, Spain

  10. 10

    Heidelberg University, Mannheim, Germany

Publication History

  1. Published Online: 6 SEP 2010
  2. Published Print: 15 OCT 2010

ISBN Information

Print ISBN: 9781405185332

Online ISBN: 9781444328394



  • neuropathic pain assessment;
  • neuropathic pain, major symptom - that may be intractable in common neurological disorders;
  • new proposal, neuropathic pain (NP) - ‘Pain arising as a direct consequence of a lesion or disease affecting somatosensory system’;
  • McGill Pain Questionnaire (MPQ), that pain quality descriptors vary across different pain conditions;
  • Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) - containing five symptom items and two clinical examination items;
  • Neuropathic Pain Questionnaire (NPQ) - 12 items (of them 10 sensory and two affective);
  • Douleur Neuropathique en 4 questions (DN4);
  • Quantitative sensory testing (QST), psychophysiological measure of perception - in response to external stimuli of controlled intensity;
  • Neuropathic Pain Symptom Inventory (NPSI) - originally validated in French;
  • pain-related reflexes, diagnostically useful for facial pains


This chapter contains sections titled:

  • Background and objectives

  • Search methods

  • Considerations on the methods of assessment in light of the new definition and grading system

  • Screening and assessment tools

  • Quantitative sensory testing

  • Neurophysiology

  • Functional neuroimaging

  • Skin biopsy

  • Conclusions

  • References