14. Pediatric Aspects of Von Willebrand Disease

  1. Augusto B. Federici MD4,
  2. Christine A. Lee MA, MD, DSc (Med), FRCP, FRCPath, FRCOGad eundem5,
  3. Erik E. Berntorp MD, PhD6,
  4. David Lillicrap MD7 and
  5. Robert R. Montgomery MD8,9
  1. Jorge Di Paola MD1 and
  2. Thomas Abshire MD2,3

Published Online: 21 MAR 2011

DOI: 10.1002/9781444329926.ch14

Von Willebrand Disease: Basic and Clinical Aspects

Von Willebrand Disease: Basic and Clinical Aspects

How to Cite

Di Paola, J. and Abshire, T. (2011) Pediatric Aspects of Von Willebrand Disease, in Von Willebrand Disease: Basic and Clinical Aspects (eds A. B. Federici, C. A. Lee, E. E. Berntorp, D. Lillicrap and R. R. Montgomery), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444329926.ch14

Editor Information

  1. 4

    Division of Hematology and Transfusion Medicine, L. Sacco University Hospital, Department of Internal Medicine, University of Milan, Milan, Italy

  2. 5

    University of London, London, UK

  3. 6

    Malmö Centre for Thrombosis and Haemostasis, Lund University, Skåne University Hospital, Malmö, Sweden

  4. 7

    Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada

  5. 8

    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA

  6. 9

    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA

Author Information

  1. 1

    University of Colorado Denver School of Medicine, The Children's Hospital, Aurora, CO, USA

  2. 2

    Medical Services and the Medical Science Institute, Milwaukee, WI, USA

  3. 3

    BloodCenter of Wisconsin, Milwaukee, WI, USA

Publication History

  1. Published Online: 21 MAR 2011
  2. Published Print: 25 MAR 2011

ISBN Information

Print ISBN: 9781405195126

Online ISBN: 9781444329926



  • mucocutaneous bleeding in children;
  • neonatal hemorrhage;
  • bleeding scores in children;
  • acquired von Willebrand disease;
  • Wilms tumor;
  • von Willebrand disease;
  • menorrhagia in teenagers;
  • DDAVP in children;
  • DDAVP and seizures;
  • von Willebrand disease prophylaxis


The diagnosis of von Willebrand disease often occurs in childhood and adolescence. There are specific aspects of the disease that are unique to these populations. The careful evaluation of family and personal history as well as a thorough physical exam will help with the correct diagnosis. Screening laboratories are not always useful, and von Willebrand factor levels should be part of the evaluation if the disease is strongly suspected. Some young children may have increased treatment-related complications. It is important to coordinate with adult hematologists in order to ensure an effective transition to adult care.