3. Von Willebrand Factor Structure and Function

  1. Augusto B. Federici MD2,
  2. Christine A. Lee MA, MD, DSc (Med), FRCP, FRCPath, FRCOGad eundem3,
  3. Erik E. Berntorp MD, PhD4,
  4. David Lillicrap MD5 and
  5. Robert R. Montgomery MD6,7
  1. Robert R. Montgomery MD6,7 and
  2. Sandra L. Haberichter PhD1

Published Online: 21 MAR 2011

DOI: 10.1002/9781444329926.ch3

Von Willebrand Disease: Basic and Clinical Aspects

Von Willebrand Disease: Basic and Clinical Aspects

How to Cite

Montgomery, R. R. and Haberichter, S. L. (2011) Von Willebrand Factor Structure and Function, in Von Willebrand Disease: Basic and Clinical Aspects (eds A. B. Federici, C. A. Lee, E. E. Berntorp, D. Lillicrap and R. R. Montgomery), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444329926.ch3

Editor Information

  1. 2

    Division of Hematology and Transfusion Medicine, L. Sacco University Hospital, Department of Internal Medicine, University of Milan, Milan, Italy

  2. 3

    University of London, London, UK

  3. 4

    Malmö Centre for Thrombosis and Haemostasis, Lund University, Skåne University Hospital, Malmö, Sweden

  4. 5

    Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen's University, Kingston, ON, Canada

  5. 6

    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA

  6. 7

    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA

Author Information

  1. 1

    Department of Pediatrics – Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA

  2. 6

    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA

  3. 7

    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA

Publication History

  1. Published Online: 21 MAR 2011
  2. Published Print: 25 MAR 2011

ISBN Information

Print ISBN: 9781405195126

Online ISBN: 9781444329926

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Keywords:

  • von Willebrand factor (VWF);
  • glycoprotein Ib receptor (GPIb);
  • VWF domain structure;
  • “beads on a string”;
  • Proteolysis of VWF;
  • Disulfide structure of VWF

Summary

This chapter contains sections titled:

  • Introduction

  • Four functions of VWF

  • Structure of VWF

  • VWF domain structure

  • Biochemistry of VWF

  • Summary

  • Acknowledgements

  • References