15. Progressive Supranuclear Palsy and Corticobasal Degeneration

  1. Dennis W. Dickson MD4 and
  2. Roy O. Weller MD, PhD, FRCPath5
  1. Dennis W. Dickson MD4,
  2. Jean-Jaques Hauw1,
  3. Yves Agid2 and
  4. Irene Litvan3

Published Online: 21 SEP 2011

DOI: 10.1002/9781444341256.ch15

Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Second Edition

Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Second Edition

How to Cite

Dickson, D. W., Hauw, J.-J., Agid, Y. and Litvan, I. (2011) Progressive Supranuclear Palsy and Corticobasal Degeneration, in Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders, Second Edition (eds D. W. Dickson and R. O. Weller), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444341256.ch15

Editor Information

  1. 4

    Departments of Pathology (Neuropathology) and Neuroscience Mayo Clinic, Jacksonville, FL, USA

  2. 5

    Clinical Neurosciences, University of Southampton School of Medicine, Southampton General Hospital, Southampton, UK

Author Information

  1. 1

    Anatomopathologie (Neurologique), Hôpital Pitiè-Salpêtrière, Paris, France

  2. 2

    Institut du Cerveau et de la Moelle épinière, Hôpital Pitié-Salpêtrière, Paris, France

  3. 3

    Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA

  4. 4

    Departments of Pathology (Neuropathology) and Neuroscience Mayo Clinic, Jacksonville, FL, USA

Publication History

  1. Published Online: 21 SEP 2011
  2. Published Print: 2 SEP 2011

ISBN Information

Print ISBN: 9781405196932

Online ISBN: 9781444341256

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Keywords:

  • progressive supranuclear palsy (PSP) and CBD;
  • CBD, akinetic-rigid parkinsonism;
  • “cortical-basal ganglionic degeneration” (CBGD);
  • Richardson's syndrome;
  • pure akinesia and gait failure (PAGF);
  • corticobasal syndrome (CBS);
  • asymmetrical atrophy in PSP-CBS;
  • astrocytic lesions;
  • Alzheimer's type pathology;
  • tau phosphorylation and dephosphorylation pathways

Summary

This chapter contains sections titled:

  • Definition

  • Synonyms and historical aspects

  • Epidemiology

  • Genetics

  • Clinical features

  • Macroscopy

  • Histopathology

  • Combined pathologies

  • Ultrastructural findings

  • Biochemistry

  • Differential diagnosis

  • Animal and experimental models

  • Pathogenesis

  • Future directions and therapy

  • References