12. Acquired Bleeding Disorders

  1. Alvin H. Schmaier MD and
  2. Hillard M. Lazarus MD, FACP
  1. Howard A. Liebman

Published Online: 22 SEP 2011

DOI: 10.1002/9781444345254.ch12

Concise Guide to Hematology

Concise Guide to Hematology

How to Cite

Liebman, H. A. (2011) Acquired Bleeding Disorders, in Concise Guide to Hematology (eds A. H. Schmaier and H. M. Lazarus), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345254.ch12

Editor Information

  1. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

Author Information

  1. Jane Anne Nohl Division of Hematology, Department of Medicine, University of Southern California-Keck School of Medicine, Los Angeles, CA, USA

Publication History

  1. Published Online: 22 SEP 2011
  2. Published Print: 4 NOV 2011

ISBN Information

Print ISBN: 9781405196666

Online ISBN: 9781444345254



  • anticoagulation;
  • disseminated intravascular coagulation;
  • liver disease;
  • vitamin K deficiency;
  • massive transfusion;
  • acquired coagulation factor inhibitors;
  • drug-induced platelet dysfunction


Acquired bleeding disorders are the most common causes of bleeding seen in the practice of hematology. These entities can be due to interference with the platelet plug formation, interference with blood coagulation proteins, and interference with both. The physician needs to be cognizant of these entities to recognize hemostatic problems arising during the course of an illness or as result of therapies. Quantitative or qualitative defects in platelet plug formation can arise from immune thrombocytopenia, drug-induced thrombocytopenia, anti-platelet medications, or interfering monoclonal immunoglobulins. Acquired defects in blood coagulation proteins can arise from anticoagulation and fibrinolytic therapies, vitamin K deficiency, massive transfusion, and acquired inhibitors. Both disseminated intravascular coagulation and liver disease contribute to acquired bleeding disorders due to defects in both platelets and blood coagulation proteins.