20. Classifi cation of Lymphoma

  1. Alvin H. Schmaier MD and
  2. Hillard M. Lazarus MD, FACP
  1. Yi-Hua Chen MD and
  2. Amy Chadburn MD

Published Online: 22 SEP 2011

DOI: 10.1002/9781444345254.ch20

Concise Guide to Hematology

Concise Guide to Hematology

How to Cite

Chen, Y.-H. and Chadburn, A. (2011) Classifi cation of Lymphoma, in Concise Guide to Hematology (eds A. H. Schmaier and H. M. Lazarus), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345254.ch20

Editor Information

  1. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

Author Information

  1. Division of Hematopathology, Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

Publication History

  1. Published Online: 22 SEP 2011
  2. Published Print: 4 NOV 2011

ISBN Information

Print ISBN: 9781405196666

Online ISBN: 9781444345254



  • classification of lymphoma;
  • precursor lymphoid neoplasm;
  • T-cell lymphoma;
  • B-cell lymphoma;
  • Hodgkin lymphoma;
  • immunophenotype;
  • cytogenetics


Lymphoma is a neoplasm derived from lymphocytes at various stages of maturation and presents primarily as a solid tumor in the lymphoid or non-lymphoid tissues. Various classification systems have been used over the years. The earliest classification systems were mainly based on the architecture and cytomorphology of the neoplastic cells. More recent classifications use a combination of morphology, immunophenotype, genetic characteristics and clinical features to define specific subtypes of lymphoma. This chapter will discuss the lymphoma classification based on the latest WHO classification which is widely adopted by oncologists and pathologists. The clinical, morphologic, immunophenotypic and genetic features of each common subtype of lymphoma are concisely summarized