22. Plasma Cell Disorders

  1. Alvin H. Schmaier MD and
  2. Hillard M. Lazarus MD, FACP
  1. Sumit Madan MD and
  2. Philip R. Greipp MD

Published Online: 22 SEP 2011

DOI: 10.1002/9781444345254.ch22

Concise Guide to Hematology

Concise Guide to Hematology

How to Cite

Madan, S. and Greipp, P. R. (2011) Plasma Cell Disorders, in Concise Guide to Hematology (eds A. H. Schmaier and H. M. Lazarus), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345254.ch22

Editor Information

  1. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

Author Information

  1. Division of Hematology, Mayo Clinic, Rochester, MN, USA

Publication History

  1. Published Online: 22 SEP 2011
  2. Published Print: 4 NOV 2011

ISBN Information

Print ISBN: 9781405196666

Online ISBN: 9781444345254



  • monoclonal gammopathy;
  • immunoglobulins;
  • multiple myeloma;
  • smoldering multiple myeloma;
  • monoclonal gammopathy of undetermined significance;
  • amyloidosis;
  • POEMS syndrome;
  • Waldenström's macroglobulinemia


Plasma cell disorders are a group of diseases characterized by the over production of the abnormal plasma cells derived from the terminal differentiation of B lymphocytes. A monoclonal (M) serum and/or urine protein almost always accompanies malignant plasma cell diseases such as multiple myeloma, amyloidosis, Waldenström's macroglobulinemia, solitary bone and extra medullary plasmacytoma, POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes) syndrome and heavy chain disease, as well as the preceding asymptomatic, premalignant disease stages such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Monoclonal gammopathy, plasma cell dyscrasia, dysproteinemias, and paraproteinemias are other terms used to describe this group of disorders.