25. Transfusion Therapy

  1. Alvin H. Schmaier MD and
  2. Hillard M. Lazarus MD, FACP
  1. Beth H. Shaz MD1,2 and
  2. Christopher D. Hillyer MD1,3

Published Online: 22 SEP 2011

DOI: 10.1002/9781444345254.ch25

Concise Guide to Hematology

Concise Guide to Hematology

How to Cite

Shaz, B. H. and Hillyer, C. D. (2011) Transfusion Therapy, in Concise Guide to Hematology (eds A. H. Schmaier and H. M. Lazarus), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345254.ch25

Editor Information

  1. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

Author Information

  1. 1

    New York Blood Center, New York, NY, USA

  2. 2

    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA

  3. 3

    Dpartment of Medicine, Weill Cornell Medical College, New York, NY, USA

Publication History

  1. Published Online: 22 SEP 2011
  2. Published Print: 4 NOV 2011

ISBN Information

Print ISBN: 9781405196666

Online ISBN: 9781444345254



  • red blood cell transfusion;
  • plasma transfusion;
  • platelet transfusion;
  • cryoprecipitate transfusion;
  • granulocyte transfusion;
  • transfusion reactions;
  • transfusion transmitted diseases;
  • transfusion adverse events;
  • Rh immune globulin


Approximately 5 million people in the US are transfused every year. Component therapy is most commonly used in order to ensure transfusion is individualized to the patient's specific needs. Blood components include red blood cells (RBC), plasma, platelets, cryoprecipitate and granulocytes. Blood transfusion is associated with multiple adverse events, both infectious and noninfectious. Thus, the benefits of transfusion must be weighed against the risks for each patient.