26. Hematopoietic Cell Transplantation

  1. Alvin H. Schmaier MD and
  2. Hillard M. Lazarus MD, FACP
  1. Hillard M. Lazarus MD, FACP

Published Online: 22 SEP 2011

DOI: 10.1002/9781444345254.ch26

Concise Guide to Hematology

Concise Guide to Hematology

How to Cite

Lazarus, H. M. (2011) Hematopoietic Cell Transplantation, in Concise Guide to Hematology (eds A. H. Schmaier and H. M. Lazarus), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345254.ch26

Editor Information

  1. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

Author Information

  1. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

Publication History

  1. Published Online: 22 SEP 2011
  2. Published Print: 4 NOV 2011

ISBN Information

Print ISBN: 9781405196666

Online ISBN: 9781444345254

SEARCH

Keywords:

  • hematopoietic cell transplantation;
  • autologous;
  • allogeneic;
  • HLA;
  • umbilical cord;
  • graft-versus-host disease

Summary

Hematopoietic cell transplantation (HCT) is a life-saving art applied as a curative treatment modality for patients with selected malignant and non-malignant diseases. The treatment and possible cure of certain malignant diseases depends upon delivering doses of chemotherapy or chemo-radiation therapy that exceed the tolerance of bone marrow. Infusion of hematopoietic cells avoids potentially fatal irreversible marrow aplasia. Formerly referred to as bone marrow transplantation, high-dose chemotherapy or chemo-radiotherapy followed by infusion of hematopoietic progenitor cells allows full lympho-hematopoietic reconstitution. Further, in the case of infusion of cells that are obtained from another person, these cells exert an “allogeneic cellular effect” and eliminate residual malignant cells. HCT also may be used to correct immune deficiency disorders such as severe combined immune deficiency syndrome (SCIDS), bone marrow failure states such as severe aplastic anemia, congenital enzyme deficiency and autoimmune diseases, hemoglobinopathies and other conditions such as multiple sclerosis.