5. Iron Deficiency

  1. Alvin H. Schmaier MD and
  2. Hillard M. Lazarus MD, FACP
  1. Alice Ma MD

Published Online: 22 SEP 2011

DOI: 10.1002/9781444345254.ch5

Concise Guide to Hematology

Concise Guide to Hematology

How to Cite

Ma, A. (2011) Iron Deficiency, in Concise Guide to Hematology (eds A. H. Schmaier and H. M. Lazarus), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345254.ch5

Editor Information

  1. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

Author Information

  1. Department of Medicine, Division of Hematology/Oncology, University of North Carolina, Chapel Hill, NC, USA

Publication History

  1. Published Online: 22 SEP 2011
  2. Published Print: 4 NOV 2011

ISBN Information

Print ISBN: 9781405196666

Online ISBN: 9781444345254



  • iron;
  • ferritin;
  • transferring;
  • iron metabolism;
  • TIBC;
  • anemia of chronic disease;
  • hepcidin


Iron deficiency occurs when the intake and absorption of iron are insufficient to replenish the body's loss of iron. When total body iron stores are depleted, the hemoglobin levels begin to fall. This chapter will cover iron metabolism, the epidemiology of iron deficiency, and iron deficiency anemia—pathophysiology, clinical manifestations, diagnosis, and treatment. Additionally, diagnostic differences between the anemia of chronic disease and thalassemia minor will be covered.