7. Congenital Hemolytic Anemias

  1. Alvin H. Schmaier MD and
  2. Hillard M. Lazarus MD, FACP
  1. Archana M. Agarwal MD1 and
  2. Josef T. Prchal MD1,2

Published Online: 22 SEP 2011

DOI: 10.1002/9781444345254.ch7

Concise Guide to Hematology

Concise Guide to Hematology

How to Cite

Agarwal, A. M. and Prchal, J. T. (2011) Congenital Hemolytic Anemias, in Concise Guide to Hematology (eds A. H. Schmaier and H. M. Lazarus), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345254.ch7

Editor Information

  1. Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA

Author Information

  1. 1

    University of Utah and ARUP Laboratories, Salt Lake City, UT, USA

  2. 2

    Huntsmar Cancer Hospital, George E. Waheln VA Medical Center, Salt Lake City, UT, USA

Publication History

  1. Published Online: 22 SEP 2011
  2. Published Print: 4 NOV 2011

ISBN Information

Print ISBN: 9781405196666

Online ISBN: 9781444345254



  • hemolysis;
  • anemia;
  • splenomegaly;
  • spherocytosis;
  • elliptocytosis;
  • pyropoikilocytosis;
  • glucose-6-phosphate dehydogenase;
  • pyruvate kinase;
  • 5' nucleotidase;
  • thalassemias;
  • sickle cell disease


Congenital hemolytic anemias result from intrinsic defects of the red blood cells. They can be due to defects of the red blood cell membrane, enzyme(s), or hemoglobin. The clinical picture depends upon the severity of the defect and the chronicity of the problem, and ranges from asymptomatic to life-threatening anemia.