10. Developmental Abnormalities

  1. Alan D. Irvine MD, FRCPI, FRCP2,3,
  2. Peter H. Hoeger MD4,5 and
  3. Albert C. Yan MD, FAAP, FAAD6,7
  1. Henning Hamm MD

Published Online: 24 MAY 2011

DOI: 10.1002/9781444345384.ch10

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

How to Cite

Hamm, H. (2011) Developmental Abnormalities, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch10

Editor Information

  1. 2

    Trinity College, Dublin, Ireland

  2. 3

    Our Lady's Children's Hospital, Dublin, Ireland

  3. 4

    University of Hamburg, Hamburg, Germany

  4. 5

    Catholic Children's Hospital Wilhelmstift, Hamburg, Germany

  5. 6

    University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  6. 7

    The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Author Information

  1. Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany

Publication History

  1. Published Online: 24 MAY 2011
  2. Published Print: 3 JUN 2011

ISBN Information

Print ISBN: 9781405176958

Online ISBN: 9781444345384



  • amniotic constriction band;
  • aplasia cutis congenita;
  • congenital cysts and sinuses;
  • cranial dysraphism;
  • cutis verticis gyrata;
  • hamartomas;
  • infantile perineal protrusion;
  • nasal glioma;
  • occult spinal dysraphism;
  • polythelia


A multitude of developmental abnormalities affects the skin. Some of them are easily visible, others are unimpressive or hidden and can therefore remain unnoticed for a while. A few anomalies, such as the transverse nasal line and precalcaneal congenital fibrolipomatous hamartoma, are merely an insignificant freak of nature but most are at least potentially associated with underlying conditions, such as cranial or spinal dysraphism, or complex syndromes, for example branchial arch malformations. The purpose of the chapter is to provide the paediatric dermatologist with profound knowledge to differentiate between harmless negligibilities and cutaneous markers of serious developmental failures. The latter may deserve rapid diagnostic evaluation and treatment to prevent grave consequences.