113. Infantile Haemangiomas and Other Vascular Tumours
- Alan D. Irvine MD, FRCPI, FRCP3,4,
- Peter H. Hoeger MD5,6,
- Albert C. Yan MD, FAAP, FAAD7,8
Published Online: 24 MAY 2011
DOI: 10.1002/9781444345384.ch113
Copyright © 2011 Blackwell Publishing Ltd
Book Title
Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition
Additional Information
How to Cite
Bruckner, A. L. and Frieden, I. J. (2011) Infantile Haemangiomas and Other Vascular Tumours, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch113
Editor Information
- 3
Trinity College, Dublin, Ireland
- 4
Our Lady's Children's Hospital, Dublin, Ireland
- 5
University of Hamburg, Hamburg, Germany
- 6
Catholic Children's Hospital Wilhelmstift, Hamburg, Germany
- 7
University of Pennsylvania School of Medicine, Philadelphia, PA, USA
- 8
The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Publication History
- Published Online: 24 MAY 2011
- Published Print: 3 JUN 2011
ISBN Information
Print ISBN: 9781405176958
Online ISBN: 9781444345384
- Summary
- Chapter
- References
Keywords:
- congenital haemangioma;
- GLUT1;
- hepatic haemangioma;
- infantile haemangioma;
- kaposiform haemangio-endothelioma;
- Kasabach–Merritt phenomenon;
- lymphangio-endotheliomatosis;
- PHACE syndrome;
- tufted angioma
Summary
Infantile haemangiomas are the most common benign tumour of infancy and follow a unique pattern of proliferation in early infancy followed by slow involution in childhood. They express GLUT1, which has helped distinguish them from other vascular tumours. Most do not require treatment but corticosteroids and propranolol are key options during proliferation if needed. Large facial and lumbosacral haemangiomas may be associated with a spectrum of developmental anomalies termed PHACE and SACRAL/PELVIS syndrome, respectively. Numerous skin haemangiomas should alert physicians to the possibility of liver haemangiomas. Kasabach-Merritt phenomenom is not a complication of infantile haemangiomas but of tufted angioma and kaposiform haemangioendothelioma.