113. Infantile Haemangiomas and Other Vascular Tumours

  1. Alan D. Irvine MD, FRCPI, FRCP3,4,
  2. Peter H. Hoeger MD5,6 and
  3. Albert C. Yan MD, FAAP, FAAD7,8
  1. Anna L. Bruckner MD1 and
  2. Ilona J. Frieden MD2

Published Online: 24 MAY 2011

DOI: 10.1002/9781444345384.ch113

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

How to Cite

Bruckner, A. L. and Frieden, I. J. (2011) Infantile Haemangiomas and Other Vascular Tumours, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch113

Editor Information

  1. 3

    Trinity College, Dublin, Ireland

  2. 4

    Our Lady's Children's Hospital, Dublin, Ireland

  3. 5

    University of Hamburg, Hamburg, Germany

  4. 6

    Catholic Children's Hospital Wilhelmstift, Hamburg, Germany

  5. 7

    University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  6. 8

    The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Author Information

  1. 1

    Departments of Dermatology and Pediatrics, Stanford University School of Medicine, Stanford, CA, USA

  2. 2

    Division of Pediatric Dermatology, San Francisco School of Medicine, University of California, San Francisco, CA, USA

Publication History

  1. Published Online: 24 MAY 2011
  2. Published Print: 3 JUN 2011

ISBN Information

Print ISBN: 9781405176958

Online ISBN: 9781444345384



  • congenital haemangioma;
  • GLUT1;
  • hepatic haemangioma;
  • infantile haemangioma;
  • kaposiform haemangio-endothelioma;
  • Kasabach–Merritt phenomenon;
  • lymphangio-endotheliomatosis;
  • PHACE syndrome;
  • tufted angioma


Infantile haemangiomas are the most common benign tumour of infancy and follow a unique pattern of proliferation in early infancy followed by slow involution in childhood. They express GLUT1, which has helped distinguish them from other vascular tumours. Most do not require treatment but corticosteroids and propranolol are key options during proliferation if needed. Large facial and lumbosacral haemangiomas may be associated with a spectrum of developmental anomalies termed PHACE and SACRAL/PELVIS syndrome, respectively. Numerous skin haemangiomas should alert physicians to the possibility of liver haemangiomas. Kasabach-Merritt phenomenom is not a complication of infantile haemangiomas but of tufted angioma and kaposiform haemangioendothelioma.