134. Premature Ageing Syndromes

  1. Alan D. Irvine MD, FRCPI, FRCP2,3,
  2. Peter H. Hoeger MD4,5 and
  3. Albert C. Yan MD, FAAP, FAAD6,7
  1. Helga V. Toriello PhD

Published Online: 24 MAY 2011

DOI: 10.1002/9781444345384.ch134

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

How to Cite

Toriello, H. V. (2011) Premature Ageing Syndromes, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch134

Editor Information

  1. 2

    Trinity College, Dublin, Ireland

  2. 3

    Our Lady's Children's Hospital, Dublin, Ireland

  3. 4

    University of Hamburg, Hamburg, Germany

  4. 5

    Catholic Children's Hospital Wilhelmstift, Hamburg, Germany

  5. 6

    University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  6. 7

    The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Author Information

  1. Department of Pediatrics/Human, Development, Michigan State University College of Human Medicine, Grand Rapids, MI, USA

Publication History

  1. Published Online: 24 MAY 2011
  2. Published Print: 3 JUN 2011

ISBN Information

Print ISBN: 9781405176958

Online ISBN: 9781444345384

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Keywords:

  • cutis laxa;
  • dysmorphic;
  • laminopathy;
  • lipoatrophy;
  • osteolysis;
  • progeria;
  • syndrome

Summary

In this chapter the various genetic conditions that are associated with a prematurely aged phenotype are described. Causes of this phenotype include true premature ageing, such as is seen in Hutchinson-Gilford syndrome; conditions with cutaneous atrophy and/or lipoatrophy; excess skin laxity, as is seen in the various forms of syndromic cutis laxa; and conditions in which an individual simply looks older than their stated age. The genetic causes of many of these conditions are known, and diagnosis is aided by the ability to do a molecular test to determine the true diagnosis. This information is provided, where known.