140. Skin Gene and Cell Therapy

  1. Alan D. Irvine MD, FRCPI, FRCP2,3,
  2. Peter H. Hoeger MD4,5,
  3. Albert C. Yan MD, FAAP, FAAD6,7
  1. Matthias Titeux,
  2. Alain Hovnanian MD, PhD

Published Online: 24 MAY 2011

DOI: 10.1002/9781444345384.ch140

Book Title

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Additional Information

How to Cite

Titeux, M. and Hovnanian, A. (2011) Skin Gene and Cell Therapy, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch140

Editor Information

  1. 2

    Trinity College, Dublin, Ireland

  2. 3

    Our Lady's Children's Hospital, Dublin, Ireland

  3. 4

    University of Hamburg, Hamburg, Germany

  4. 5

    Catholic Children's Hospital Wilhelmstift, Hamburg, Germany

  5. 6

    University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  6. 7

    The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Author Information

  1. Department of Dermatology and Genetics, Inserm U781, Necker Hospital for Sick Children, University Paris V – Rene Descartés, Paris, France

Publication History

  1. Published Online: 24 MAY 2011
  2. Published Print: 3 JUN 2011

ISBN Information

Print ISBN: 9781405176958

Online ISBN: 9781444345384

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CHAPTER TOOLS

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Keywords:

  • skin gene and cell therapy;
  • skin, target for gene and cell therapy - cutaneous and systemic diseases;
  • preclinical studies, successful - non-Herlitz junctional epidermolysis bullosa;
  • dendritic cell populations - powerful antigen-presenting cell (APCs);
  • virus-mediated transfer - viruses, templates designing gene therapy vectors;
  • delivery methods - for skin gene therapy;
  • human parvovirus adeno-associated virus (AAV) - Parvoviridae family;
  • herpes simplex virus amplicons - transfer of large DNA constructs;
  • gene editing, transforming - mutant allele into normal one, genomic organization of gene;
  • skin-equivalent grafting

Summary

This chapter contains sections titled:

  • Introduction

  • Delivery methods

  • Skin gene therapy applications

  • Conclusion

  • References

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