181. Principles of Paediatric Dermatological Therapy

  1. Alan D. Irvine MD, FRCPI, FRCP3,4,
  2. Peter H. Hoeger MD5,6 and
  3. Albert C. Yan MD, FAAP, FAAD7,8
  1. Dennis P. West MD, PhD1,
  2. Candrice Heath MD1,
  3. Ann Cameron Haley BA1,
  4. Anne Mahoney1 and
  5. Giuseppe Micali MD2

Published Online: 24 MAY 2011

DOI: 10.1002/9781444345384.ch181

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

How to Cite

West, D. P., Heath, C., Cameron Haley, A., Mahoney, A. and Micali, G. (2011) Principles of Paediatric Dermatological Therapy, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch181

Editor Information

  1. 3

    Trinity College, Dublin, Ireland

  2. 4

    Our Lady's Children's Hospital, Dublin, Ireland

  3. 5

    University of Hamburg, Hamburg, Germany

  4. 6

    Catholic Children's Hospital Wilhelmstift, Hamburg, Germany

  5. 7

    University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  6. 8

    The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Author Information

  1. 1

    Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

  2. 2

    Dermatology Clinic, University of Catania, Catania, Italy

Publication History

  1. Published Online: 24 MAY 2011
  2. Published Print: 3 JUN 2011

ISBN Information

Print ISBN: 9781405176958

Online ISBN: 9781444345384



  • paediatric dermatological therapy principles;
  • therapeutic approach to paediatric patient - newborn, or infant;
  • skin disorder treatment in paediatric patients - restoring physiological state of skin;
  • barrier properties of skin;
  • drugs, permeating stratum corneum at rates - by lipid–water coefficients;
  • factors, affecting drug penetration into skin;
  • drug penetration, anatomical sites - stratum corneum thickness;
  • vehicle, medium in which active medicament - application to skin surface;
  • topical dermatological therapeutic agents;
  • vitamin D3 analogues, topical use - calcitriol, calcipotriol and tacalcitol


This chapter contains sections titled:

  • Principles of therapy

  • Barrier properties of skin

  • Factors affecting drug penetration into skin (Box 181.1)

  • Systemic delivery of drugs through skin

  • Transdermal therapeutic systems

  • Skin metabolism of drugs

  • Vehicles

  • Topical dermatological therapeutic agents

  • Systemic therapeutic agents

  • Conclusion

  • References