47. Human Papillomavirus Infection

  1. Alan D. Irvine MD, FRCPI, FRCP2,3,
  2. Peter H. Hoeger MD4,5 and
  3. Albert C. Yan MD, FAAP, FAAD6,7
  1. Zsuzsanna Z. Szalai MD, PhD

Published Online: 24 MAY 2011

DOI: 10.1002/9781444345384.ch47

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

How to Cite

Szalai, Z. Z. (2011) Human Papillomavirus Infection, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch47

Editor Information

  1. 2

    Trinity College, Dublin, Ireland

  2. 3

    Our Lady's Children's Hospital, Dublin, Ireland

  3. 4

    University of Hamburg, Hamburg, Germany

  4. 5

    Catholic Children's Hospital Wilhelmstift, Hamburg, Germany

  5. 6

    University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  6. 7

    The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Author Information

  1. Department of Dermatology, Heim Pál Children's Hospital, Budapest, Hungary

Publication History

  1. Published Online: 24 MAY 2011
  2. Published Print: 3 JUN 2011

ISBN Information

Print ISBN: 9781405176958

Online ISBN: 9781444345384



  • children;
  • education;
  • epidemiology;
  • genital warts;
  • guidelines;
  • HPV infections;
  • papillomavirus;
  • systemic therapy;
  • topical treatment;
  • verruca vulgaris


Cutaneous viral warts are caused by human papillomavirus, which is an intracellular DNA virus. The epidemiology of warts has changed over the past years. The virus infects human squamous cells, causing a variety of clinical diseases. Over 200 human papillomavirus types have been characterized, about 20 of which are commonly identified in paediatric skin lesions. Warts appear in various forms on different sites of the body and include common warts (verruca vulgaris), plane or flat warts, myrmecia, plantar warts, coalesced mosaic warts, filiform warts, periungual warts, anogenital warts (venereal or condyloma acuminata), oral warts and respiratory papillomas. The infected host produces antibodies and a cell-mediated immune response against human papillomavirus. The infection can be subclinical, while the mode of transmission can be horizontal or vertical.

The therapy of human papillomavirus infections includes destructive, antiviral, antiproliferative and immunstimulative agents. The disease is widespread; human papillomavirus infections must be screened carefully.