50. Gianotti–Crosti Syndrome

  1. Alan D. Irvine MD, FRCPI, FRCP3,4,
  2. Peter H. Hoeger MD5,6 and
  3. Albert C. Yan MD, FAAP, FAAD7,8
  1. Carlo M. Gelmetti MD1,2

Published Online: 24 MAY 2011

DOI: 10.1002/9781444345384.ch50

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

How to Cite

Gelmetti, C. M. (2011) Gianotti–Crosti Syndrome, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch50

Editor Information

  1. 3

    Trinity College, Dublin, Ireland

  2. 4

    Our Lady's Children's Hospital, Dublin, Ireland

  3. 5

    University of Hamburg, Hamburg, Germany

  4. 6

    Catholic Children's Hospital Wilhelmstift, Hamburg, Germany

  5. 7

    University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  6. 8

    The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Author Information

  1. 1

    Department of Anesthesia, Intensive Care and Dermatologic Sciences, Università degli Studi di Milano, Milan, Italy

  2. 2

    Unit of Pediatric Dermatology, Fondazione IRCCS Ca' Granda Ospedale, Maggiore Policlinico, Milan, Italy

Publication History

  1. Published Online: 24 MAY 2011
  2. Published Print: 3 JUN 2011

ISBN Information

Print ISBN: 9781405176958

Online ISBN: 9781444345384



  • Gianotti–Crosti syndrome;
  • papular acrodermatitis of childhood;
  • infantile papular acrodermatitis;
  • papulovesicular acrolocated syndrome;
  • viral exanthem


Gianotti-Crosti syndrome is a distinctive viral exanthem of childhood that is characterized by papular or papulovesicular lesions that are most prominent on the face, buttocks and extremities. Initially described in association with Hepatitis B virus, to date is more commonly caused by Epstein–Barr virus. The rash develops within a week and fades with mild desquamation in 3–4 weeks without treatment. Constitutional symptoms are usually mild or absent; pruritus, if present, is not disturbing. Henoch–Schönlein purpura, erythema multiforme and hand–foot–mouth disease should be considered in the differential diagnosis.