81. Psoriasis: Pathogenesis

  1. Alan D. Irvine MD, FRCPI, FRCP3,4,
  2. Peter H. Hoeger MD5,6 and
  3. Albert C. Yan MD, FAAP, FAAD7,8
  1. Flora B. de Waard-van der Spek MD, PhD1 and
  2. Arnold P. Oranje MD, PhD2

Published Online: 24 MAY 2011

DOI: 10.1002/9781444345384.ch81

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition

How to Cite

de Waard-van der Spek, F. B. and Oranje, A. P. (2011) Psoriasis: Pathogenesis, in Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition (eds A. D. Irvine, P. H. Hoeger and A. C. Yan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444345384.ch81

Editor Information

  1. 3

    Trinity College, Dublin, Ireland

  2. 4

    Our Lady's Children's Hospital, Dublin, Ireland

  3. 5

    University of Hamburg, Hamburg, Germany

  4. 6

    Catholic Children's Hospital Wilhelmstift, Hamburg, Germany

  5. 7

    University of Pennsylvania School of Medicine, Philadelphia, PA, USA

  6. 8

    The Children's Hospital of Philadelphia, Philadelphia, PA, USA

Author Information

  1. 1

    Department of Dermatology, Erasmus MC, Rotterdam, The Netherlands

  2. 2

    Professor of Pediatric Dermatology, Department of Pediatrics, Erasmus MC, Sophia Children's Hospital, Rotterdam, The Netherlands

Publication History

  1. Published Online: 24 MAY 2011
  2. Published Print: 3 JUN 2011

ISBN Information

Print ISBN: 9781405176958

Online ISBN: 9781444345384



  • psoriasis;
  • aetiology;
  • pathogenesis;
  • genetics;
  • Th1 response;
  • antigen-presenting cells;
  • environmental factors


In this chapter the aetiology and pathogenesis of psoriasis are discussed. Accumulating evidence indicates that psoriasis is a multifactorial disorder caused by the concerted action of multiple disease genes in a single individual, triggered by environmental factors.

In the past, abnormalities in keratinization were considered the etiopathogenic basis of psoriasis; however, it is now currently thought that it is initially an immune affection mediated by type Th1 response. Recently, new data have led to the assumption that antigen-presenting cells are important not only in the induction of psoriasis but also in its maintenance.