18. Esophageal Involvement in Systemic Diseases

  1. Joel E. Richter MD, FACP, MACG4,5 and
  2. Donald O. Castell MD6
  1. Siva Doma MD1,
  2. John M. Wo MD2 and
  3. Henry P. Parkman MD3

Published Online: 28 MAR 2012

DOI: 10.1002/9781444346220.ch18

The Esophagus, Fifth Edition

The Esophagus, Fifth Edition

How to Cite

Doma, S., Wo, J. M. and Parkman, H. P. (2012) Esophageal Involvement in Systemic Diseases, in The Esophagus, Fifth Edition (eds J. E. Richter and D. O. Castell), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346220.ch18

Editor Information

  1. 4

    Division of Digestive Diseases and Nutrition, USA

  2. 5

    Joy McCann Culverhouse Center for Swallowing Disorders, University of South Florida, Tampa, FL, USA

  3. 6

    Esophageal Disorders Program, Division of Gastroenterology, Department of Internal Medicine, Medical University of South Carolina, Charleston, SC, USA

Author Information

  1. 1

    Temple University School of Medicine, Gastroenterology Section, Philadelphia, PA, USA

  2. 2

    Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY, USA

  3. 3

    Gastrointestinal Section, Temple University School of Medicine, Philadelphia, PA, USA

Publication History

  1. Published Online: 28 MAR 2012
  2. Published Print: 4 MAR 2012

ISBN Information

Print ISBN: 9781405198646

Online ISBN: 9781444346220



  • esophagus;
  • systemic diseases;
  • amyloidosis;
  • scleroderma;
  • systemic sclerosis


Systemic diseases can affect any part of the gastrointestinal system, including the esophagus. Clinical manifestations of systemic disorders affecting the esophagus can range from debilitating symptoms, such as severe dysphagia with associated weight loss, to asymptomatic esophageal dysmotility. Evaluation of the esophagus may permit diagnosis of a systemic disorder, such as scleroderma. This chapter reviews the esophageal manifestations of systemic diseases, including connective tissue diseases, endocrine and metabolic diseases, inflammatory diseases, neuromuscular disorders, and dermatologic disorders. Pathogenesis, pathology, clinical manifestations, diagnostic features, and treatments are discussed.