22. Treatment of Miscellaneous Idiopathic Headache Disorders

  1. Nils Erik Gilhus MD, PHD7,8,
  2. Michael P. Barnes MD, FRCP9,10 and
  3. Michael Brainin MD11,12,13
  1. S. Evers1,
  2. P. Goadsby2,
  3. R. Jensen3,
  4. A. May4,
  5. J. Pascual5 and
  6. G. Sixt6

Published Online: 21 SEP 2011

DOI: 10.1002/9781444346268.ch22

European Handbook of Neurological Management, Volume 2, Second Edition

European Handbook of Neurological Management, Volume 2, Second Edition

How to Cite

Evers, S., Goadsby, P., Jensen, R., May, A., Pascual, J. and Sixt, G. (2011) Treatment of Miscellaneous Idiopathic Headache Disorders, in European Handbook of Neurological Management, Volume 2, Second Edition (eds N. E. Gilhus, M. P. Barnes and M. Brainin), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346268.ch22

Editor Information

  1. 7

    Department of Clinical Medicine, University of Bergen, Norway

  2. 8

    Department of Neurology, Haukeland University Hospital, Bergen, Norway

  3. 9

    University of Newcastle, Newcastle upon Tyne, UK

  4. 10

    Hunters Moor Neurorehabilitation Ltd, Newcastle upon Tyne, UK

  5. 11

    Department of Clinical Medicine and Prevention, Austria

  6. 12

    Center for Clinical Neurosciences, Donau-Universität Krems, Austria

  7. 13

    Department of Neurology, Landesklinikum Donauregion Tulln, Tulln, Austria

Author Information

  1. 1

    University of Münster, Münster, Germany

  2. 2

    University of California, San Francisco CA, USA and UCL, Institute of Neurology, Queen Square, London, UK

  3. 3

    Glostrup Hospital, University of Copenhagen, Denmark

  4. 4

    University of Hamburg, Hamburg, Germany

  5. 5

    University Hospital ‘Central de Asturias’, Oviedo, Spain

  6. 6

    Regional Hospital, Bolzano, Italy

  1. Group 4 of the IHS classification.

Publication History

  1. Published Online: 21 SEP 2011
  2. Published Print: 30 SEP 2011

ISBN Information

Print ISBN: 9781405185349

Online ISBN: 9781444346268



  • headache classification;
  • idiopathic headache;
  • indomethacin;
  • treatment recommendations


Background: Certain miscellaneous idiopathic headache disorders, which are regarded as entities, are grouped in Chapter 4 of the International Classification of Headache Disorders. Recent epidemiological research suggests that these headache disorders are underdiagnosed.

Objectives: To give expert recommendations for the different drug and non-drug treatment procedures of these different headache disorders based on a literature search and on consensus of an expert panel.

Methods: Medical reference systems were screened for all kinds of clinical studies on these headache disorders. The findings were evaluated according to the recommendations of the EFNS resulting in Level A, B or C recommendations and good practice points.

Recommendations: For all headache disorders, acute and prophylactic drug treatment is recommended, based on case series and expert consensus. Furthermore, recommendations for the differential diagnoses are given since these headache disorders can also present with a symptomatic form. The most effective drug for the majority of these headache disorders is indomethacin, mostly applied as long-term or short-term prophylaxis.