12. Abnormal Liver Function Tests: Diagnostic Approach

  1. John N. Plevris MD, PhD, FRCPE, FEBGH3 and
  2. Colin W. Howden MD, FRCP (Glasg.), FACP, AGAF, FACG4
  1. Timothy T. Gordon-Walker MBChB, BSc1 and
  2. John P. Iredale DM, FRCP, FMedSci2

Published Online: 29 NOV 2011

DOI: 10.1002/9781444346381.ch12

Problem-Based Approach to Gastroenterology and Hepatology

Problem-Based Approach to Gastroenterology and Hepatology

How to Cite

Gordon-Walker, T. T. and Iredale, J. P. (2012) Abnormal Liver Function Tests: Diagnostic Approach, in Problem-Based Approach to Gastroenterology and Hepatology (eds J. N. Plevris and C. W. Howden), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346381.ch12

Editor Information

  1. 3

    Centre for Liver and Digestive Disorders, The Royal Infirmary of Edinburgh, Edinburgh, Scotland, UK

  2. 4

    Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

Author Information

  1. 1

    The Royal Infi rmary of Edinburgh, UK

  2. 2

    Tissue Injury and Regeneration Group, MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, Scotland, UK

Publication History

  1. Published Online: 29 NOV 2011
  2. Published Print: 17 JAN 2012

ISBN Information

Print ISBN: 9781405182270

Online ISBN: 9781444346381

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Keywords:

  • liver function tests;
  • hepatitis;
  • cholestasis;
  • cirrhosis;
  • hemochromatosis;
  • autoimmune hepatitis;
  • primary sclerosing cholangitis;
  • primary biliary cirrhosis;
  • pregnancy

Summary

In this chapter we consider the interpretation of liver function test (LFT) abnormalities in relation to a series of common clinical cases. The chapter outlines the origin and significance of routine LFT, and presents a systematic approach to the interpretation and investigation of abnormal ones. We consider how best to approach the interpretation and investigation of asymptomatic patients with LFT abnormalities. Furthermore, we consider in more detail the investigation and management of specific liver conditions, including some metabolic, autoimmune, and pregnancy-related liver diseases.