10. Epithelial Cells

  1. Kenji Izuhara MD, PhD3,
  2. Stephen T. Holgate MD, DSc, FMedSci4 and
  3. Marsha Wills-Karp PhD5
  1. Tillie-Louise Hackett PhD1,
  2. Stephanie Warner BSc2,
  3. Dorota Stefanowicz BSc2 and
  4. Darryl Knight PhD1

Published Online: 27 JUL 2011

DOI: 10.1002/9781444346688.ch10

Inflammation and Allergy Drug Design

Inflammation and Allergy Drug Design

How to Cite

Hackett, T.-L., Warner, S., Stefanowicz, D. and Knight, D. (2011) Epithelial Cells, in Inflammation and Allergy Drug Design (eds K. Izuhara, S. T. Holgate and M. Wills-Karp), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346688.ch10

Editor Information

  1. 3

    Department of Biomolecular Sciences, Division of Medical Biochemistry, Saga Medical School, Nabeshima, Saga, Japan

  2. 4

    School of Medicine, Allergy and Inflammation Research, Southampton General Hospital, University Medicine, Southampton, UK

  3. 5

    Division of Immunology, Cincinnati Children's Medical Center, Cincinnati, OH, USA

Author Information

  1. 1

    Department of Anesthesiology, Pharmacology and Therapeutics, UBC James Hogg Research Centre, Providence Heart and Lung Institute, University of British Columbia Vancouver, BC, Canada

  2. 2

    UBC James Hogg Research Centre, Providence Heart and Lung Institute, Department of Medicine, University of British Columbia, Vancouver, BC, Canada

Publication History

  1. Published Online: 27 JUL 2011
  2. Published Print: 13 AUG 2011

ISBN Information

Print ISBN: 9781444330144

Online ISBN: 9781444346688



  • epithelial cells, and alterations - in structural cells of airways, epithelium acting in concert with abnormal immune responses;
  • epithelial barrier, interface - between external environment and internal milieu of lung;
  • allergens, with proteolytic activity as Der p 1 - from house dust mite, proteases from pollen, disrupting mucosal integrity;
  • asthmatic airway epithelium composition - different, from nondiseased airways;
  • goblet cell hyperplasia, mucus production in excess - asthma, and morbidity and mortality;
  • epithelial immune barrier - exposure to external environment;
  • epithelial repair and stem cells - epithelial turnover, being very slow;
  • genetic and epigenetic factors - influencing airway epithelium, positional cloning and genome-wide association;
  • PCDH1, recently being identified - as asthma susceptibility gene;
  • gene expression, epigenetic regulation - generating recent attention