21. Epithelial Growth Factors

  1. Kenji Izuhara MD, PhD3,
  2. Stephen T. Holgate MD, DSc, FMedSci4 and
  3. Marsha Wills-Karp PhD5
  1. Yasuhiro Gon MD1 and
  2. Shu Hashimoto MD2

Published Online: 27 JUL 2011

DOI: 10.1002/9781444346688.ch21

Inflammation and Allergy Drug Design

Inflammation and Allergy Drug Design

How to Cite

Gon, Y. and Hashimoto, S. (2011) Epithelial Growth Factors, in Inflammation and Allergy Drug Design (eds K. Izuhara, S. T. Holgate and M. Wills-Karp), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346688.ch21

Editor Information

  1. 3

    Department of Biomolecular Sciences, Division of Medical Biochemistry, Saga Medical School, Nabeshima, Saga, Japan

  2. 4

    School of Medicine, Allergy and Inflammation Research, Southampton General Hospital, University Medicine, Southampton, UK

  3. 5

    Division of Immunology, Cincinnati Children's Medical Center, Cincinnati, OH, USA

Author Information

  1. 1

    Department of Internal Medicine, Division of General Medicine, Nihon University School of Medicine, Tokyo, Japan

  2. 2

    Department of Internal Medicine, Division of Respiratory Medicine, Nihon University School of Medicine, Tokyo, Japan

Publication History

  1. Published Online: 27 JUL 2011
  2. Published Print: 13 AUG 2011

ISBN Information

Print ISBN: 9781444330144

Online ISBN: 9781444346688

SEARCH

Keywords:

  • epithelial growth factors;
  • asthma and chronic obstructive pulmonary disease (COPD) - chronic inflammatory diseases of lungs;
  • airway inflammation, type of lymphocytic infiltration - T helper 2 (Th2) lymphocytes, secreting cytokines;
  • epidermal growth factors, their receptors - understanding of EGF, and its receptor, EGFR;
  • epidermal growth factors - involved in lung development;
  • EGFR pathway, key target - in non-small-cell lung cancer;
  • interleukin 8, important neutrophil chemoattractant - in patients' sputum;
  • epithelial wound repair - via epithelial growth factor receptor signaling;
  • dsRNA, by viral RNA polymerases - intermediary, in genome replication of RNA viruses;
  • EGFR on airway, and effects - new therapeutic target, in chronic airway inflammatory diseases

Summary

Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases of the lungs characterized by persistent airway inflammation, structural remodeling of the airway wall, and airflow obstruction. Airway remodeling is an ongoing repair process in reaction to inflammation, and several epithelial growth factors and cytokines have been reported to be overexpressed in airway epithelial tissues of individuals with asthma and COPD. Among these growth factors, epidermal growth factor (EGF) and its receptor (EGFR) are one of the most important factors in the pathogenesis of airway remodeling. As the details become clearer regarding the roles of EGFR pathways in the repair process of damaged airway epithelia and in the regulation of mucus production, EGFR is drawing greater attention as an important target for the treatment of airway remodeling in individuals with asthma and COPD.