25. Toll-Like Receptors

  1. Kenji Izuhara MD, PhD3,
  2. Stephen T. Holgate MD, DSc, FMedSci4 and
  3. Marsha Wills-Karp PhD5
  1. Jessica L. Allen PhD1,
  2. Aurelien Trompette MS2 and
  3. Christopher L. Karp MD1

Published Online: 27 JUL 2011

DOI: 10.1002/9781444346688.ch25

Inflammation and Allergy Drug Design

Inflammation and Allergy Drug Design

How to Cite

Allen, J. L., Trompette, A. and Karp, C. L. (2011) Toll-Like Receptors, in Inflammation and Allergy Drug Design (eds K. Izuhara, S. T. Holgate and M. Wills-Karp), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346688.ch25

Editor Information

  1. 3

    Department of Biomolecular Sciences, Division of Medical Biochemistry, Saga Medical School, Nabeshima, Saga, Japan

  2. 4

    School of Medicine, Allergy and Inflammation Research, Southampton General Hospital, University Medicine, Southampton, UK

  3. 5

    Division of Immunology, Cincinnati Children's Medical Center, Cincinnati, OH, USA

Author Information

  1. 1

    Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, USA

  2. 2

    University Hospital Center of Lausanne, Lausanne, Switzerland

Publication History

  1. Published Online: 27 JUL 2011
  2. Published Print: 13 AUG 2011

ISBN Information

Print ISBN: 9781444330144

Online ISBN: 9781444346688

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Keywords:

  • Toll-like receptors - molecular identification of receptors, and microbial infection;
  • Toll-like receptors (TLRs) - lines of evidence, epidemiologic, genetic;
  • immune recognition in innate - and adaptive immune systems;
  • avoidance of harmful recognition of self - by adaptive immune system, prevention by “immunologic tolerance”;
  • innate immune systems, recognition - via germ line;
  • Janeway's schema, innate immune recognition - via pattern recognition receptors (PRRs), and ligands being pathogen-associated molecular patterns (PAMPs);
  • Toll-like receptors, basic biology - Toll homologs, and TLRs, identified and cloned;
  • Toll-like receptor signaling - ligand-induced TLR dimerization, creating a TIR–TIR platform;
  • toll-like receptors, atopy and asthma - epidemiologic and genetic data;
  • toll-like receptors and allergenicity - intimate link, TLR signaling and allergic sensitization