3. Importance of Th17- and Th1-Associated Responses for the Development of Asthma

  1. Kenji Izuhara MD, PhD4,
  2. Stephen T. Holgate MD, DSc, FMedSci5 and
  3. Marsha Wills-Karp PhD6
  1. Tomohiro Yoshimoto MD, PhD1,
  2. Hiroko Tsutsui MD, PhD2 and
  3. Kenji Nakanishi MD, PhD3

Published Online: 27 JUL 2011

DOI: 10.1002/9781444346688.ch3

Inflammation and Allergy Drug Design

Inflammation and Allergy Drug Design

How to Cite

Yoshimoto, T., Tsutsui, H. and Nakanishi, K. (2011) Importance of Th17- and Th1-Associated Responses for the Development of Asthma, in Inflammation and Allergy Drug Design (eds K. Izuhara, S. T. Holgate and M. Wills-Karp), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346688.ch3

Editor Information

  1. 4

    Department of Biomolecular Sciences, Division of Medical Biochemistry, Saga Medical School, Nabeshima, Saga, Japan

  2. 5

    School of Medicine, Allergy and Inflammation Research, Southampton General Hospital, University Medicine, Southampton, UK

  3. 6

    Division of Immunology, Cincinnati Children's Medical Center, Cincinnati, OH, USA

Author Information

  1. 1

    Laboratory of Allergic Diseases, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

  2. 2

    Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

  3. 3

    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

Publication History

  1. Published Online: 27 JUL 2011
  2. Published Print: 13 AUG 2011

ISBN Information

Print ISBN: 9781444330144

Online ISBN: 9781444346688

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Keywords:

  • Th17 importance - and Th1-associated responses in asthma development;
  • two distinct T helper (Th) cell subsets - definite cytokine profile;
  • Th17 cells - and Th17 cell development;
  • IL-23R expression, on activated memory Th cells - or already differentiated Th17 cells;
  • IL-17 and IL-17 R, on stimulation - Th17 cells, producing members of IL-17 family;
  • Th17 cells, and allergic diseases - in respiratory tract, Th17 associated c ytokines in allergic asthma;
  • Th17 - associated cytokines in severe asthma;
  • symptom heterogeneity, and asthma - atopic and nonatopic type, or eosinophilic and noneosinophilic type;
  • super T helper 1 (Th1) cells - activated with antigen, together with interleukin 18 (IL-18);
  • positive relationship, between IL-18 levels - lesion, circulation, asthma, allergic rhinitis and atopic dermatitis (AD)

Summary

Bronchial asthma was believed to be mediated by Th2 cells and their cytokines. However, other subsets of CD4+ T cells, such as T helper 17 (Th17) cells, regulatory T cells, and Th1-derived cells with unique functional properties, are now recognized as having a role in the modulation of atopic diseases exemplified by asthma and atopic dermatitis. In this chapter, we focus on Th17 cells and recently identified subpopulation of Th1 cells that express both Th1 and Th2 cytokines in response to the engagement via their T-cell receptor and interleukin 18 receptor (IL-18R) and review their roles in the pathogenesis of bronchial asthma.