5. A Role for Natural Killer T-Cell Subsets in the Pathogenesis of Various Allergic Disorders

  1. Kenji Izuhara MD, PhD5,
  2. Stephen T. Holgate MD, DSc, FMedSci6 and
  3. Marsha Wills-Karp PhD7
  1. Hiroshi Watarai PhD1,
  2. Michishige Harada PhD1,2,
  3. Mayumi Tamari MD, PhD3 and
  4. Masaru Taniguchi MD, PhD4

Published Online: 27 JUL 2011

DOI: 10.1002/9781444346688.ch5

Inflammation and Allergy Drug Design

Inflammation and Allergy Drug Design

How to Cite

Watarai, H., Harada, M., Tamari, M. and Taniguchi, M. (2011) A Role for Natural Killer T-Cell Subsets in the Pathogenesis of Various Allergic Disorders, in Inflammation and Allergy Drug Design (eds K. Izuhara, S. T. Holgate and M. Wills-Karp), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346688.ch5

Editor Information

  1. 5

    Department of Biomolecular Sciences, Division of Medical Biochemistry, Saga Medical School, Nabeshima, Saga, Japan

  2. 6

    School of Medicine, Allergy and Inflammation Research, Southampton General Hospital, University Medicine, Southampton, UK

  3. 7

    Division of Immunology, Cincinnati Children's Medical Center, Cincinnati, OH, USA

Author Information

  1. 1

    Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan

  2. 2

    Center for Genome Medicine, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan

  3. 3

    Laboratory for Respiratory Diseases, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan

  4. 4

    RIKEN Research Center for Allergy and Immunology, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan

Publication History

  1. Published Online: 27 JUL 2011
  2. Published Print: 13 AUG 2011

ISBN Information

Print ISBN: 9781444330144

Online ISBN: 9781444346688

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Keywords:

  • role for Natural killer T (NKT) cell subsets - in allergic disorder pathogenesis;
  • NKT cell function, bridging innate and acquired immunity NKT cells - characterized by conserved single variant T-cell receptor (TCR);
  • feature of NKT cells - promiscuous production of T helper cell (Th)1, Th2, and Th17 cytokines;
  • second signal, and key event - determining NKT cell function;
  • IL-17 RB+ NKT cells - IL-17 RB+ NKT cells, inducing AHR in response to IL-25;
  • IL-17 RB+ NKT cells - as potential target, for allergy and asthma therapy;
  • IL-17 RB polymorphisms, associated with corticosteroid - resistance in childhood asthma;
  • other NKT cell subset involvement - in disease pathogenesis, NKT cells inducing airway neutropilia;
  • thymic stromal lymphopoietin (TSLP) - epithelial cell-derived cytokine, activating DCs;
  • AHR, induced by allergens, air pollution (ozone) and viral infection - NKT cells, common disease mechanism for airway inflammation

Summary

Natural killer T (NKT) cells characterized by their recognition of endogenous glycolipid ligands are a unique autoreactive lymphocyte subset. NKT cells are currently proposed to be subdivided into distinct phenotypical and functional subsets, each producing a different profile of cytokines depending on extrinsic factors as a second signal. Herein, we review recent studies and describe a new paradigm in allergic pathogenesis involving newly defined interleukin (IL) 17RB+ NKT cells as an important effector cell type for inflammatory diseases.