8. Eosinophils

  1. Kenji Izuhara MD, PhD5,
  2. Stephen T. Holgate MD, DSc, FMedSci6 and
  3. Marsha Wills-Karp PhD7
  1. Nancy A. Lee PhD1,
  2. Mark V. Dahl MD2,
  3. Elizabeth A. Jacobsen PhD3 and
  4. Sergei I. Ochkur PhD4

Published Online: 27 JUL 2011

DOI: 10.1002/9781444346688.ch8

Inflammation and Allergy Drug Design

Inflammation and Allergy Drug Design

How to Cite

Lee, N. A., Dahl, M. V., Jacobsen, E. A. and Ochkur, S. I. (2011) Eosinophils, in Inflammation and Allergy Drug Design (eds K. Izuhara, S. T. Holgate and M. Wills-Karp), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346688.ch8

Editor Information

  1. 5

    Department of Biomolecular Sciences, Division of Medical Biochemistry, Saga Medical School, Nabeshima, Saga, Japan

  2. 6

    School of Medicine, Allergy and Inflammation Research, Southampton General Hospital, University Medicine, Southampton, UK

  3. 7

    Division of Immunology, Cincinnati Children's Medical Center, Cincinnati, OH, USA

Author Information

  1. 1

    Division of Hematology and Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Samuel C. Johnson Medical Research Building, Scottsdale, AZ, USA

  2. 2

    Department of Immunology, Dermatology, and Pathology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Samuel C. Johnson Medical Research Building, Scottsdale, AZ, USA

  3. 3

    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Samuel C. Johnson Medical Research Building, Scottsdale, AZ, USA

  4. 4

    Department of Biochemistry and Molecular Biology, Division of Pulmonary Medicine, Mayo Clinic Arizona, Samuel C. Johnson Medical Research Building, Scottsdale, AZ, USA

Publication History

  1. Published Online: 27 JUL 2011
  2. Published Print: 13 AUG 2011

ISBN Information

Print ISBN: 9781444330144

Online ISBN: 9781444346688

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Keywords:

  • eosinophils, classical view of eosinophils - as destructive effector cells, killing cells or tissues indiscriminately;
  • eosinophil presence, in airway allergic disease - and inflammation in respiratory tract;
  • eosinophils and asthma - disease of lungs and airways, pathologies outside lungs, as well;
  • asthma in humans, three groups - nonatopic allergic asthma, asthma associated with allergies and atopic asthma;
  • T cells, and eosinophils - key immune modulators and remodeling agents in asthma;
  • eosinophil numbers, increasing in presence - of allergic disease, as asthma, AD and hay fever;
  • nonallergic asthma, not often responsive - to prednisone treatment;
  • allergic, nonatopic asthma - allergic asthma, observed in atopic patients;
  • T cells, integral role - in asthmatic inflammation;
  • eosinophils and T cells - cooperating in asthmatic inflammation