9. Basophils in Inflammation and Allergy Drug Design

  1. Kenji Izuhara MD, PhD2,
  2. Stephen T. Holgate MD, DSc, FMedSci3 and
  3. Marsha Wills-Karp PhD4
  1. Donald MacGlashan Jr. MD

Published Online: 27 JUL 2011

DOI: 10.1002/9781444346688.ch9

Inflammation and Allergy Drug Design

Inflammation and Allergy Drug Design

How to Cite

MacGlashan, D. (2011) Basophils in Inflammation and Allergy Drug Design, in Inflammation and Allergy Drug Design (eds K. Izuhara, S. T. Holgate and M. Wills-Karp), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346688.ch9

Editor Information

  1. 2

    Department of Biomolecular Sciences, Division of Medical Biochemistry, Saga Medical School, Nabeshima, Saga, Japan

  2. 3

    School of Medicine, Allergy and Inflammation Research, Southampton General Hospital, University Medicine, Southampton, UK

  3. 4

    Division of Immunology, Cincinnati Children's Medical Center, Cincinnati, OH, USA

Author Information

  1. Johns Hopkins University, Baltimore, MD, USA

Publication History

  1. Published Online: 27 JUL 2011
  2. Published Print: 13 AUG 2011

ISBN Information

Print ISBN: 9781444330144

Online ISBN: 9781444346688

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Keywords:

  • basophils in inflammation - and allergy drug design, basophils versus mast cells;
  • mediators of inflammatory response - three classes of mediators, from basophils and metabolites of arachidonic acid;
  • cytokine release, coincident - with degranulation and rapid;
  • basophils and innate immune response - IgE-mediated response in basophils, the way cells can be stimulated to secrete mediators;
  • functionally active ligands (or their receptors) - on human basophils;
  • roles of basophils in immune response - classic primary immune response (T cells, B cells, and antigen-presenting cells [APCs]);
  • basophil function modulation - receptors in basophils, inducing mediator release, inducing cytokine release;
  • IL-3, regulating pre-Golgi pool of FcεRIα;
  • Syk expression, a weak correlation - with levels of Syk mRNA, regulating Syk in basophils;
  • Syk regulation on basophils - opportunity for selective manipulation

Summary

Basophils are an important effector cell in the allergic reaction. Recent studies in mice have also suggested that they may be important in both primary and secondary adaptive immune responses owing to their capacity to release interleukin 4 (IL-4) and IL-13. Over the last several decades, many of the receptors and ligands that either directly activate or modulate the function of these cells have been identified. Furthermore, several signaling pathways that are initiated during FcεRI-mediated activation have been identified that may offer new ways to modulate the immunoglobulin E (IgE)-mediated response of these cells. In addition, better understanding of the controls on FcεRI expression also offer some therapeutic approaches to regulate basophil functions.