11. Focal Salvage Cryoablation in Recurrent Prostate Cancer

  1. Hashim U Ahmed MRCS, BM, BCh, BA(Hons)2,
  2. Manit Arya FRCS, FRCS(Urol)3,
  3. Peter Carroll MD, MPH4 and
  4. Mark Emberton FRCS (Urol), FRCS, MD, MBBS, BSc2,5
  1. Katsuto Shinohara MD

Published Online: 10 NOV 2011

DOI: 10.1002/9781444346893.ch11

Focal Therapy in Prostate Cancer

Focal Therapy in Prostate Cancer

How to Cite

Shinohara, K. (2011) Focal Salvage Cryoablation in Recurrent Prostate Cancer, in Focal Therapy in Prostate Cancer (eds H. U. Ahmed, M. Arya, P. Carroll and M. Emberton), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346893.ch11

Editor Information

  1. 2

    Division of Surgery and Interventional Sciences, University College London, London, UK

  2. 3

    Department of Urology, University College London, London, UK

  3. 4

    Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA

  4. 5

    NIHR UCL/UCH Comprehensive Biomedical Research Centre, London, UK

Author Information

  1. Department of Urology and Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA

Publication History

  1. Published Online: 10 NOV 2011
  2. Published Print: 2 OCT 2011

ISBN Information

Print ISBN: 9781405196499

Online ISBN: 9781444346893

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Keywords:

  • prostate cancer;
  • local recurrence;
  • radiation therapy;
  • cryoablation;
  • salvage therapy;
  • focal therapy;
  • partial cryoablation

Summary

Salvage therapy for locally recurrent prostate adenocarcinoma after radiation is associated with significant risk of complications. Cryoablation has been applied for salvage treatment as an alternative minimally invasive option. However, even with advances in technology, salvage cryoablation can be associated with unpredictable side effects, which have a profound effect on quality of life. In order to minimize the risk of complications, focal cryoablation was tried in 27 patients with local recurrence diagnosed in only one lobe. In properly selected patients with unilateral focus of recurrent disease after radiation therapy, acceptable oncologic results can be achieved with minimum morbidity by focal cryoablation of the prostate.