17. Determining Success of Focal Therapy: Imaging

  1. Hashim U Ahmed MRCS, BM, BCh, BA(Hons)2,
  2. Manit Arya FRCS, FRCS(Urol)3,
  3. Peter Carroll MD, MPH4 and
  4. Mark Emberton FRCS (Urol), FRCS, MD, MBBS, BSc2,5
  1. Alex Kirkham BM, BCh, FRCS, FRCR, MD and
  2. Clare Allen MD, FRCR, BM, BCh

Published Online: 10 NOV 2011

DOI: 10.1002/9781444346893.ch17

Focal Therapy in Prostate Cancer

Focal Therapy in Prostate Cancer

How to Cite

Kirkham, A. and Allen, C. (2011) Determining Success of Focal Therapy: Imaging, in Focal Therapy in Prostate Cancer (eds H. U. Ahmed, M. Arya, P. Carroll and M. Emberton), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346893.ch17

Editor Information

  1. 2

    Division of Surgery and Interventional Sciences, University College London, London, UK

  2. 3

    Department of Urology, University College London, London, UK

  3. 4

    Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA

  4. 5

    NIHR UCL/UCH Comprehensive Biomedical Research Centre, London, UK

Author Information

  1. Department of Radiology, University College London Hospitals NHS, Foundation Trust, London, UK

Publication History

  1. Published Online: 10 NOV 2011
  2. Published Print: 2 OCT 2011

ISBN Information

Print ISBN: 9781405196499

Online ISBN: 9781444346893



  • posttreatment imaging;
  • MRI;
  • contrast enhancement;
  • diffusion weighting;
  • necrosis;
  • microbubble ultrasound enhancement;
  • local recurrence;
  • residual cancer;
  • HIFU;
  • PDT;
  • cryosurgery;
  • radiotherapy;
  • laser


Imaging has often had only a minor role in the management of prostate cancer—for example, to stage disease once diagnosed or for directing a standardized set of biopsies. For focal treatment the paradigm changes, and at the very least the therapy itself is image directed. We would go further and see it playing a key role both before (in the detection and targeted diagnosis of disease), during (targeting), and after focal therapy (evaluating the treatment effect and detecting residual or recurrent disease). The first two aspects have been covered in earlier chapters of this book, and we will make the case for the central role of imaging in the third.