7. Localization of Cancer within the Prostate: Dynamic Contrast-Enhanced MRI

  1. Hashim U Ahmed MRCS, BM, BCh, BA(Hons)6,
  2. Manit Arya FRCS, FRCS(Urol)7,
  3. Peter Carroll MD, MPH8 and
  4. Mark Emberton FRCS (Urol), FRCS, MD, MBBS, BSc6,9
  1. Philippe Puech MD, PhD1,2,
  2. Anwar Padhani MBBS, FRCR3,
  3. Laurent Lemaitre MD, PhD4,
  4. Nacim Betrouni PhD2,
  5. Pierre Colin MD5 and
  6. Arnauld Villers MD, PhD5

Published Online: 10 NOV 2011

DOI: 10.1002/9781444346893.ch7

Focal Therapy in Prostate Cancer

Focal Therapy in Prostate Cancer

How to Cite

Puech, P., Padhani, A., Lemaitre, L., Betrouni, N., Colin, P. and Villers, A. (2011) Localization of Cancer within the Prostate: Dynamic Contrast-Enhanced MRI, in Focal Therapy in Prostate Cancer (eds H. U. Ahmed, M. Arya, P. Carroll and M. Emberton), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444346893.ch7

Editor Information

  1. 6

    Division of Surgery and Interventional Sciences, University College London, London, UK

  2. 7

    Department of Urology, University College London, London, UK

  3. 8

    Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA

  4. 9

    NIHR UCL/UCH Comprehensive Biomedical Research Centre, London, UK

Author Information

  1. 1

    CHRU Lille, University of Lille Nord de France, Lille, France

  2. 2

    INSERM, University of Lille Nord de France, Lille, France

  3. 3

    Paul Strickland Imaging Centre, Mount Vernon Cancer Centre, Northwood, Middlesex, UK

  4. 4

    Department of Radiology, University of Lille Nord de France, Lille, France

  5. 5

    Department of Urology, CHRU Lille, University of Lille Nord de France, Lille, France

Publication History

  1. Published Online: 10 NOV 2011
  2. Published Print: 2 OCT 2011

ISBN Information

Print ISBN: 9781405196499

Online ISBN: 9781444346893

SEARCH

Keywords:

  • imaging;
  • dynamic contrast enhancement;
  • DCE;
  • perfusion MRI;
  • gadolinium;
  • magnetic resonance;
  • functional MRI;
  • multiparametric MRI;
  • computer-assisted diagnosis;
  • computer-assisted therapy;
  • laser therapy;
  • radiotherapy

Summary

Dynamic contrast-enhanced MRI has become a mainstream clinical tool with recognized indications in the imaging of prostate cancer as a part of multiparametric imaging. This technique has successfully moved from research to an easy-to-use routine tool at 1.5T or 3T. Current roles include lesion localization, staging (depiction of capsular penetration and seminal vesicle invasion), and the detection of suspected tumor recurrence following definitive treatment. Limitations of the technique include difficulties in differentiating prostatitis from cancer in the peripheral gland and distinguishing between benign prostatic hyperplasia and transition zone tumors, as well as yet nonstandardized interpretation and reporting techniques. Both may be overcome or attenuated in a near future, by using prostate-dedicated computer-assisted diagnosis software.