11. Metabolic Syndrome and Mental Illness
- Christopher D. Byrne FRCP, FRCPath, PhD3 and
- Sarah H. Wild FRCPE, FFPH, PhD4
Published Online: 10 JUN 2011
Copyright © 2011 Blackwell Publishing Ltd.
The Metabolic Syndrome, Second Edition
How to Cite
Holt, R. I. G. and Peveler, R. C. (2011) Metabolic Syndrome and Mental Illness, in The Metabolic Syndrome, Second Edition (eds C. D. Byrne and S. H. Wild), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444347319.ch11
Institute for Developmental Sciences, Southampton General Hospital, Southampton, UK
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland, UK
- Published Online: 10 JUN 2011
- Published Print: 12 AUG 2011
Print ISBN: 9781444336580
Online ISBN: 9781444347319
- bipolar illness;
Diabetes and cardiovascular disease occur 2–3-fold more frequently among people with either depression or more severe psychiatric illnesses, such as schizophrenia and bipolar illness. Much of the excess risk can be ascribed to an increase in traditional lifestyle risk factors; however, genetics may also contribute to some of the risk. Mental illnesses are associated with neuroendocrine changes, such as hypercortisolemia and increased catecholamines, and chronic inflammation which may play an important role in the etiology of the metabolic syndrome. Anti-psychotic treatment, particularly the newer second generation anti-psychotics, has been implicated in the development of features of the metabolic syndrome, but overall treatment with second generation anti-psychotics is associated with decreased cardiovascular mortality. It is important to screen and treat cardiovascular risk factors actively in people with mental illness.