4. The B Cell Response to Transplantation Antigens

  1. Bruce Kaplan MD, PhD4,5,
  2. Gilbert J. Burckart PharmD6 and
  3. Fadi G. Lakkis MD7
  1. Roger Sciammas PhD1,
  2. Anita S. Chong PhD1 and
  3. Robert B. Colvin MD2,3

Published Online: 19 APR 2012

DOI: 10.1002/9781444355628.ch4

Immunotherapy in Transplantation: Principles and Practice

Immunotherapy in Transplantation: Principles and Practice

How to Cite

Sciammas, R., Chong, A. S. and Colvin, R. B. (2010) The B Cell Response to Transplantation Antigens, in Immunotherapy in Transplantation: Principles and Practice (eds B. Kaplan, G. J. Burckart and F. G. Lakkis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444355628.ch4

Editor Information

  1. 4

    University of Arizona Medical Center Tucson, AZ, USA

  2. 5

    Applied Genomics Center, University of Alberta Edmonton, AB, Canada

  3. 6

    Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA

  4. 7

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA

Author Information

  1. 1

    University of Chicago, Chicago, IL, USA

  2. 2

    Massachusetts General Hospital, Boston, MA, USA

  3. 3

    Harvard Medical School, Boston, MA, USA

Publication History

  1. Published Online: 19 APR 2012
  2. Published Print: 16 APR 2010

ISBN Information

Print ISBN: 9781405182713

Online ISBN: 9781444355628



  • B cell;
  • antibody;
  • complement;
  • plasma cell;
  • rejection


Transplantation, historically attributed to be T cell driven, is experiencing a revision regarding the criticality of B cells. This reconsideration has evolved in part from the unexpected benefits of preventing allograft rejection by specific targeting of B cells. These functional observations, coupled with strong correlations between incidence of graft dysfunction and the presence of high titers of donor-specific antibody and complement C4d deposition in the allograft, suggest that controlling B cell activity during transplantation may be necessary to improving our current immunosuppression protocols. In this review, we describe the fundamental features of B cell biology and discuss how they pertain to transplantation.