1. Neurobiology of Chronic Pelvic Pain

  1. Paolo Vercellini
  1. Jennifer Gunter MD, FRCS(C), FACOG, DABPM

Published Online: 21 MAR 2011

DOI: 10.1002/9781444391855.ch1

Chronic Pelvic Pain

Chronic Pelvic Pain

How to Cite

Gunter, J. (2011) Neurobiology of Chronic Pelvic Pain, in Chronic Pelvic Pain (ed P. Vercellini), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444391855.ch1

Editor Information

  1. Istituto “Luigi Mangiagalli”, Fondazione IRCCS Ca' Granda, University of Milan, Italy

Author Information

  1. Kaiser San Francisco Medical Center, San Francisco, California, USA

Publication History

  1. Published Online: 21 MAR 2011
  2. Published Print: 23 MAR 2011

Book Series:

  1. Gynecology in Practice

Book Series Editors:

  1. Aydin Arici

ISBN Information

Print ISBN: 9781444330663

Online ISBN: 9781444391855



  • Neurobiology of Chronic Pelvic Pain;
  • Nociception and pain;
  • wide dynamic range neurons (WDRs);
  • gamma - aminobutyric acid (GABA);
  • central nervous system (CNS);
  • N-methyl-d-aspartate (NMDA);
  • gene-related peptide (CGRP);
  • pseudorabies virus (PRV)


The International Association for the Study of Pain defines pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in term of that damage. Chronic pain is much more than noxious nociception; it is a complex condition with sensory, adaptive, and affective components. Whereas acute pain has biologic utility, chronic pain does not appear to confer any evolutionary advantage.