11. Physiologic Basis of Ovulation Induction

  1. Emre Seli MD4,5,6
  1. Robert F. Casper MD1,2,3

Published Online: 8 MAR 2011

DOI: 10.1002/9781444393958.ch11

Infertility

Infertility

How to Cite

Casper, R. F. (2011) Physiologic Basis of Ovulation Induction, in Infertility (ed E. Seli), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393958.ch11

Editor Information

  1. 4

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA

  2. 5

    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut, USA

  3. 6

    Oocyte Donation and Gestational Surrogacy Program, Yale University School of Medicine, New Haven, Connecticut, USA

Author Information

  1. 1

    Division of Reproductive Sciences, University of Toronto, Canada

  2. 2

    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada

  3. 3

    Toronto Centre for Advanced Reproductive Technologies, Tornonto, Canada

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 23 MAR 2011

Book Series:

  1. Gynecology in Practice

Book Series Editors:

  1. Aydin Arici

ISBN Information

Print ISBN: 9781444333534

Online ISBN: 9781444393958

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Keywords:

  • physiologic basis of ovulation induction;
  • fertility drugs, inducing ovulation - augmenting ovulation in case of assisted reproductive technologies;
  • follicle stimulating hormone (FSH) receptors - theca cells developing luteinizing hormone (LH) receptors;
  • injectable gonadotropin preparations - on market for fertility use, urinary-derived or recombinant human FSH with or without addition of LH/hCG activity;
  • WHO classification of anovulation - women in WHO group I, defects at level of hypothalamus/pituitary;
  • pharmacokinetics of clomiphene citrate (CC) and mechanism of action of clomiphene citrate;
  • adverse effects and risks of clomiphene citrate treatment;
  • ovulation induction - with aromatase inhibitors;
  • aromatase inhibitors for IVF - in breast cancer patients;
  • adverse effects - using aromatase inhibitors for induction of ovulation

Summary

Ovulation is a key aspect of reproduction and is required for fertility. Aberrations from normal ovulatory function need to be identified, described, and appropriately treated in order to achieve pregnancy. A multitude of approaches for ovulation induction exist, including clomiphene citrate, aromatase inhibitors, and injectable gonadotropins.