12. Intrauterine Insemination

  1. Emre Seli MD6,7,8
  1. Joelle Safi MD1,
  2. Rakesh K. Sharma MD2,3 and
  3. Ashok Agarwal PhD4,5

Published Online: 8 MAR 2011

DOI: 10.1002/9781444393958.ch12



How to Cite

Safi, J., Sharma, R. K. and Agarwal, A. (2011) Intrauterine Insemination, in Infertility (ed E. Seli), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393958.ch12

Editor Information

  1. 6

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA

  2. 7

    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut, USA

  3. 8

    Oocyte Donation and Gestational Surrogacy Program, Yale University School of Medicine, New Haven, Connecticut, USA

Author Information

  1. 1

    Intern, Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio, USA

  2. 2

    Center for Reproductive Medicine, Glickman Urological & Kidney Institute, USA

  3. 3

    Ob/Gyn and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio, USA

  4. 4

    Center for Reproductive Medicine, USA

  5. 5

    Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio, USA

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 23 MAR 2011

Book Series:

  1. Gynecology in Practice

Book Series Editors:

  1. Aydin Arici

ISBN Information

Print ISBN: 9781444333534

Online ISBN: 9781444393958



  • intrauterine insemination;
  • intrauterine insemination (IUI) - one of the simplest, most commonly performed assisted conception methods;
  • cervical factor infertility - cervix serving as effective barrier against sperm;
  • IUI, less invasive and less expensive - than other invasive assisted reproductive technology (ART) procedures;
  • mechanisms of infertility - and possible IUI solutions;
  • controlled ovarian hyperstimulation (COH) - for couples with unexplained infertility;
  • natural cycles versus controlled ovarian hyperstimulation;
  • semen parameters and processing - predictive semen parameters;
  • IUI protocols - single versus double insemination;
  • risks and complications of IUI


Intrauterine insemination (IUI) is one of the simplest and most commonly performed assisted reproduction techniques. It is employed in numerous infertility causes, such as cervical factor infertility, male factor subfertility, and sexual dysfunction, and is used as a first-line therapy in unexplained infertility. Different IUI protocols exist, all of which can be applied in natural or stimulated cycles. There are minimal risks to the procedure itself, although the two major risks are ovarian hyperstimulation syndrome and multiple pregnancies. IUI has proved to be a cost-effective and safe method of assisted conception.