17. Fertility Preservation

  1. Emre Seli MD1,2,3
  1. Emre Seli MD1,2,3

Published Online: 8 MAR 2011

DOI: 10.1002/9781444393958.ch17

Infertility

Infertility

How to Cite

Seli, E. (2011) Fertility Preservation, in Infertility (ed E. Seli), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393958.ch17

Editor Information

  1. 1

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA

  2. 2

    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut, USA

  3. 3

    Oocyte Donation and Gestational Surrogacy Program, Yale University School of Medicine, New Haven, Connecticut, USA

Author Information

  1. 1

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA

  2. 2

    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut, USA

  3. 3

    Oocyte Donation and Gestational Surrogacy Program, Yale University School of Medicine, New Haven, Connecticut, USA

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 23 MAR 2011

Book Series:

  1. Gynecology in Practice

Book Series Editors:

  1. Aydin Arici

ISBN Information

Print ISBN: 9781444333534

Online ISBN: 9781444393958

SEARCH

Keywords:

  • fertility preservation;
  • strategies for fertility preservation - in women diagnosed with cancer;
  • fertility preservation options - cryopreservation of embryos or oocyte embryo cryopreservation;
  • embryo cryopreservation - and pitfalls;
  • oocyte cryopreservation - and avoiding need for sperms;
  • vitrification, alternative oocyte cryopreservation technique - preventing ice formation, improving oocyte survival;
  • ovarian tissue cryopreservation - immature oocytes within primordial follicles, advantage over embryo and oocyte freezing;
  • orthotopic (pelvic) transplantation;
  • xenotransplantation (from Greek meaning “foreign”) - transplantation of living cells;
  • fertility preservation in women - diagnosed with cancer, use of GnRH agonist (GnRHa) cotreatment with chemotherapy

Summary

Fertility preservation in females diagnosed with cancer has become increasingly important as a result of the improving cancer survival rates, combined with delayed childbearing. In addition to embryo cryopreservation combined with conventional or alternative ovarian stimulation strategies, encouraging findings have recently been reported using oocyte cryopreservation, ovarian cryopreservation, and gonadotropin releasing hormone agonist cotreatment with chemotherapy. Improvement of these techniques as well as better characterization of their success rates and risks awaits further investigation.