2. Evaluation of the Infertile Couple

  1. Emre Seli MD2,3,4
  1. Michelle L. Matthews MD

Published Online: 8 MAR 2011

DOI: 10.1002/9781444393958.ch2



How to Cite

Matthews, M. L. (2011) Evaluation of the Infertile Couple, in Infertility (ed E. Seli), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393958.ch2

Editor Information

  1. 2

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA

  2. 3

    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut, USA

  3. 4

    Oocyte Donation and Gestational Surrogacy Program, Yale University School of Medicine, New Haven, Connecticut, USA

Author Information

  1. Reproductive Endocrinology, Carolinas Medical Center, Charlotte, North Carolina, USA

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 23 MAR 2011

Book Series:

  1. Gynecology in Practice

Book Series Editors:

  1. Aydin Arici

ISBN Information

Print ISBN: 9781444333534

Online ISBN: 9781444393958



  • evaluation of the infertile couple;
  • infertility, as 1 year of unprotected intercourse - without conception;
  • evaluation tailored to patient's history - age and duration of infertility, cost-effective and evidence-based;
  • infertile couples and evaluation;
  • ovulatory infertility, detected in infertile women - common etiology for female factor infertility;
  • ovulation detection test (OVT) - or basal body temperature (BBT) charting;
  • fallopian tube assessment - tubal disease, for 15% of female infertility;
  • endometrial biopsy, the “gold standard” - in assessing ovulation;
  • uterine cavity, assessed by HSG - transvaginal ultrasound or SIS;
  • cervical factors - relatively infrequent causes of infertility


Infertility is a common condition that warrants accurate evaluation and treatment. Evaluation should be initiated after 1 year of unprotected intercourse without conception. It is appropriate to initiate an evaluation after 6 months of infertility for women over the age of 35 years or for women with a history of oligomenorrhea or amenorrhea, a partner who is known to be subfertile, or known uterine/tubal disease or endometriosis Current recommendations for evaluation are reviewed with an evidence-based approach.