6. Diagnosis and Management of Infertility due to Anovulation

  1. Emre Seli MD3,4,5
  1. Alfredo Guillén Antón1 and
  2. Juan Antonio García Velasco MD, PhD2

Published Online: 8 MAR 2011

DOI: 10.1002/9781444393958.ch6



How to Cite

Guillén Antón, A. and García Velasco, J. A. (2011) Diagnosis and Management of Infertility due to Anovulation, in Infertility (ed E. Seli), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393958.ch6

Editor Information

  1. 3

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA

  2. 4

    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut, USA

  3. 5

    Oocyte Donation and Gestational Surrogacy Program, Yale University School of Medicine, New Haven, Connecticut, USA

Author Information

  1. 1

    Instituto Valenciano de Infertilidad, IVI Madrid, Madrid, Spain

  2. 2

    Rey Juan Carlos University and IVI-Madrid, Madrid, Spain

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 23 MAR 2011

Book Series:

  1. Gynecology in Practice

Book Series Editors:

  1. Aydin Arici

ISBN Information

Print ISBN: 9781444333534

Online ISBN: 9781444393958



  • infertility, diagnosis and management - due to anovulation;
  • ovulation, final process of orchestrated cascade of signals - from hypothalamic–pituitary axis to ovaries;
  • hypogonadotropic hypogonadal anovulation (WHO group I) - strenuous exercise and/or weight loss;
  • WHO classification of ovulatory disorders;
  • hypogonadotropic hypogonadism, and anosmia (Kallman syndrome) - rare hereditary condition;
  • premature ovarian failure causes;
  • polycystic ovary syndrome (WHO group II) - PCOS, most common disorders in women of reproductive age;
  • criteria for metabolic syndrome - in women with PCOS;
  • ovulatory disorder treatment - WHO group I anovulation;
  • surgical ovarian wedge resection - established treatment for anovulatory PCOS patients


Ovulatory disorders account for about 30% of infertility problems. A valuable therapeutic guide is provided by the World Health Organization classification.

The most common disorder is polycystic ovary syndrome. Lifestyle changes and simple treatments can be offered as a first approach for many couples. However, other anovulatory disorders are not suitable for ovulation induction. Oocyte donation appears to be a realistic option for these patients.