7. Diagnosis and Management of Infertility due to Diminished Ovarian Reserve

  1. Emre Seli MD3,4,5
  1. Deidre A. Conway MD1 and
  2. Mousa I. Shamonki MD, FACOG2

Published Online: 8 MAR 2011

DOI: 10.1002/9781444393958.ch7

Infertility

Infertility

How to Cite

Conway, D. A. and Shamonki, M. I. (2011) Diagnosis and Management of Infertility due to Diminished Ovarian Reserve, in Infertility (ed E. Seli), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393958.ch7

Editor Information

  1. 3

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA

  2. 4

    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut, USA

  3. 5

    Oocyte Donation and Gestational Surrogacy Program, Yale University School of Medicine, New Haven, Connecticut, USA

Author Information

  1. 1

    Reproductive Endocrinology and Infertility, University of California, Los Angeles, California, USA

  2. 2

    In Vitro Fertilization and Assisted Reproduction, University of California, Los Angeles, California, USA

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 23 MAR 2011

Book Series:

  1. Gynecology in Practice

Book Series Editors:

  1. Aydin Arici

ISBN Information

Print ISBN: 9781444333534

Online ISBN: 9781444393958

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Keywords:

  • infertility, diagnosis and management - and diminished ovarian reserve;
  • diminished ovarian reserve - its potential treatment options;
  • ovarian physiology and ovarian follicle pool - germ cells in human ovaries;
  • follicle absence, increasing length between cycles or missed menses - menopausal transition;
  • menopausal transition - gradual decline in follicle pool;
  • patient's age, predicting ovarian reserve - and response to fertility treatment;
  • basal follicle - stimulating hormone levels;
  • Inhibin B, dimeric polypeptide - transforming growth factor-beta (TGF-β) superfamily;
  • IVF protocols, for diminished ovarian reserve - high gonadotropin dose protocol;
  • pretreatment with dehydroepiandrosterone (DHEA) - oocyte and embryo yield improvement in patients using DHEA supplementation

Summary

Diminished ovarian reserve is an important cause of female infertility and one that is difficult to treat. A multitude of laboratory and radiologic criteria are used to assess ovarian reserve, predict response to stimulation, and diagnose diminished ovarian reserve. In most cases, treatment of diminished ovarian reserve involves assisted reproductive technologies using various stimulation strategies.