8. Diagnosis and Management of Male Infertility

  1. Emre Seli MD2,3,4
  1. Herman Tournaye MD, PhD

Published Online: 8 MAR 2011

DOI: 10.1002/9781444393958.ch8



How to Cite

Tournaye, H. (2011) Diagnosis and Management of Male Infertility, in Infertility (ed E. Seli), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393958.ch8

Editor Information

  1. 2

    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA

  2. 3

    Division of Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, Connecticut, USA

  3. 4

    Oocyte Donation and Gestational Surrogacy Program, Yale University School of Medicine, New Haven, Connecticut, USA

Author Information

  1. Developmental Biology and Reproductive Sciences, Centre for Reproductive Medicine, VUB University Hospital, Brussels, Belgium

Publication History

  1. Published Online: 8 MAR 2011
  2. Published Print: 23 MAR 2011

Book Series:

  1. Gynecology in Practice

Book Series Editors:

  1. Aydin Arici

ISBN Information

Print ISBN: 9781444333534

Online ISBN: 9781444393958



  • male infertility - diagnosis and management;
  • problems, in the male partner - sole cause, or contributing cause of a couple's infertility;
  • factors - indicative of a male factor;
  • history-taking and examination in the male;
  • WHO 2010 reference values for sperms;
  • risk factors, indicative of endocrine disorder - in clinical work-up;
  • interpretation of endocrine tests - assessing pituitary–gonadal axis;
  • DNA damage testing, tool in evaluation - of infertile males;
  • ejaculatory failure, in men - with spinal cord injury, diabetes or multiple sclerosis;
  • intrauterine insemination (IUI), efficient technique - increasing fecundity in couples with male subfertility


Despite our growing knowledge of spermatogenesis and sperm function, the treatment options for male infertility remain limited. Semen analysis remains the cornerstone in evaluating male fertility. Men with abnormal semen analysis should undergo appropriate clinical work-up. First, lifestyle and potentially interfering female factors should be corrected. Then, whenever an evidence-based therapy is available, any specific cause interfering with sperm output or function should be treated. Finally, although they are not evidence-based, assisted reproductive techniques can be used to alleviate long-standing male infertility