15. The Coagulopathy of Chronic Liver Disease. Is the Long and Widely Held Belief Being Dispelled?

  1. Roberto de Franchis MD, AGAF Professor of Gastroenterology Head
  1. Armando Tripodi PhD

Published Online: 17 NOV 2010

DOI: 10.1002/9781444393989.ch15

Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition

Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition

How to Cite

Tripodi, A. (2011) The Coagulopathy of Chronic Liver Disease. Is the Long and Widely Held Belief Being Dispelled?, in Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition (ed R. de Franchis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393989.ch15

Editor Information

  1. Department of Medical Sciences, University of Milan, and Gastroenterology 3 Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Foundation, Milan, Italy

Author Information

  1. Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Department of Internal Medicine, IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation, and University of Milan, Italy

Publication History

  1. Published Online: 17 NOV 2010
  2. Published Print: 14 JAN 2011

ISBN Information

Print ISBN: 9781444334494

Online ISBN: 9781444393989

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Keywords:

  • coagulopathy of chronic liver disease - widely held belief being dispelled;
  • coagulation factors, synthesized by liver - notable exception of factor VIII and von Willebrand factor;
  • chronic liver disease, impaired synthesis - of coagulation factors and thrombocytopenia;
  • conventional haemostasis tests - skin bleeding time, prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet count;
  • abnormal values for above tests - laboratory indexes, in predicting bleeding;
  • hyper- rather than hypocoagulability - distinctive feature of chronic liver disease;
  • hypercoagulability extent, associated with stable chronic liver disease - estimated by thrombin generation test;
  • coagulation in patients with stable chronic liver disease - rebalanced, concomitant reduction of pro- and anticoagulant proteins;
  • recent guidelines, platelets a major concern - liver biopsy in patients with chronic liver disease

Summary

This chapter contains sections titled:

  • Introduction

  • How the dogma was born and how it is challenged

  • Hyper-rather than hypocoagulability seems to be the distinctive feature of chronic liver disease

  • Concluding remarks

  • References