15. The Coagulopathy of Chronic Liver Disease. Is the Long and Widely Held Belief Being Dispelled?
- Roberto de Franchis MD, AGAF Professor of Gastroenterology Head
Published Online: 17 NOV 2010
DOI: 10.1002/9781444393989.ch15
Copyright © 2011 Blackwell Publishing Ltd
Book Title
Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition
Additional Information
How to Cite
Tripodi, A. (2011) The Coagulopathy of Chronic Liver Disease. Is the Long and Widely Held Belief Being Dispelled?, in Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition (ed R. de Franchis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393989.ch15
Editor Information
Department of Medical Sciences, University of Milan, and Gastroenterology 3 Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Foundation, Milan, Italy
Publication History
- Published Online: 17 NOV 2010
- Published Print: 14 JAN 2011
ISBN Information
Print ISBN: 9781444334494
Online ISBN: 9781444393989
- Summary
- Chapter
- References
Keywords:
- coagulopathy of chronic liver disease - widely held belief being dispelled;
- coagulation factors, synthesized by liver - notable exception of factor VIII and von Willebrand factor;
- chronic liver disease, impaired synthesis - of coagulation factors and thrombocytopenia;
- conventional haemostasis tests - skin bleeding time, prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet count;
- abnormal values for above tests - laboratory indexes, in predicting bleeding;
- hyper- rather than hypocoagulability - distinctive feature of chronic liver disease;
- hypercoagulability extent, associated with stable chronic liver disease - estimated by thrombin generation test;
- coagulation in patients with stable chronic liver disease - rebalanced, concomitant reduction of pro- and anticoagulant proteins;
- recent guidelines, platelets a major concern - liver biopsy in patients with chronic liver disease
Summary
This chapter contains sections titled:
Introduction
How the dogma was born and how it is challenged
Hyper-rather than hypocoagulability seems to be the distinctive feature of chronic liver disease
Concluding remarks
References